European Spine Journal

, Volume 18, Issue 4, pp 449–464 | Cite as

Bone graft substitutes in anterior cervical discectomy and fusion

  • Anthony M. T. Chau
  • Ralph J. MobbsEmail author
Review Article


Anterior cervical discectomy with fusion is a common surgical procedure for patients suffering pain and/or neurological deficits and unresponsive to conservative management. For decades, autologous bone grafted from the iliac crest has been used as a substrate for cervical arthrodesis. However patient dissatisfaction with donor site morbidity has led to the search for alternative techniques. We present a literature review examining the progress of available grafting options as assessed in human clinical trials, considering allograft-based, synthetic, factor- and cell-based technologies.


Cervical Discectomy Spinal fusion Bone graft Anterior cervical discectomy and fusion 


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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  1. 1.University of New South WalesSydneyAustralia
  2. 2.Department of Neurosurgery, Spine UnitPrince of Wales Private HospitalSydneyAustralia

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