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European Spine Journal

, Volume 16, Issue 10, pp 1563–1569 | Cite as

Elevated soluble receptor activator of nuclear factor-κB ligand and reduced bone mineral density in patients with adolescent idiopathic scoliosis

  • Kuen Tak Suh
  • Sang-Sup Lee
  • Sang Hyun Hwang
  • Seong-Jang Kim
  • Jung Sub Lee
Original Article

Abstract

Generalized low bone mass and osteopenia in both axial and peripheral skeleton in adolescent idiopathic scoliosis (AIS) have been reported in literature. However, the exact mechanisms and causes of the bone loss in AIS are not identified yet. Therefore, this study examined the relationship between serum concentration of soluble receptor activator of nuclear factor-κB ligand (RANKL), serum level of osteoprotegerin (OPG) and bone mass in 72 patients with AIS and compared to those of 64 age- and gender-matched healthy controls. The mean lumbar spinal bone mineral density (LSBMD) and femoral neck BMD (FNBMD) in patients with AIS were decreased compared with that in control individuals, respectively (P = 0.0029 and P = 0.0192, respectively). The mean RANKL and RANKL to OPG ratio in patients with AIS were increased compared with that in control subjects, respectively (P = 0.0004 and P = 0.0032, respectively). The RANKL and RANKL to OPG ratios were negatively correlated to the LSBMD and serum OPG levels in both groups. Serum OPG levels were positively correlated to the LSBMD and FNBMD in both groups. These findings mean that the imbalance and the disturbed interaction of RANKL and OPG may be an important cause and pathogenesis in reduced BMD in AIS.

Keywords

Adolescent idiopathic scoliosis Bone mineral density RANKL OPG 

Notes

Acknowledgments

K. T. Suh, S.-S. Lee and S. H. Hwang contributed equally to this study. This study was supported by Medical Research Institute Grant (2007-12), Pusan National University.

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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Kuen Tak Suh
    • 1
  • Sang-Sup Lee
    • 2
  • Sang Hyun Hwang
    • 3
  • Seong-Jang Kim
    • 4
  • Jung Sub Lee
    • 1
  1. 1.Department of Orthopaedic SurgeryPusan National University School of MedicinePusanRepublic of Korea
  2. 2.Department of Environmental EngineeringPusan National University, College of EngineeringPusanRepublic of Korea
  3. 3.Department of Laboratoy MedicinePusan National University School of MedicinePusanRepublic of Korea
  4. 4.Department of Nuclear MedicinePusan National University School of MedicinePusanRepublic of Korea

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