European Spine Journal

, Volume 16, Issue 3, pp 405–409 | Cite as

Primary bone tumours of the spine: a 42-year survey from the Leeds Regional Bone Tumour Registry

  • Simon P. Kelley
  • Robert U. Ashford
  • Abhay S. Rao
  • Robert A. Dickson
Original Article


We conducted a review of the Leeds Regional Bone Tumour Registry for primary bone tumours of the spine since establishment in 1958 until year 2000. To analyse the incidence of primary tumours of the spine and to record the site of occurrence, sex distribution, survival and pathology of these tumours. Primary tumours of the spine are particularly rare, accounting for between 4 and 13% of published series of primary bone tumours. The Leeds Bone Tumour Registry was reviewed and a total of 2,750 cases of bone tumours and tumour-like cases were analysed. Consultants in orthopaedic surgery, neurosurgery, oncology and pathology in North and West Yorkshire and Humberside contribute to the Registry. Primary bone tumours of the osseous spine constitute only 126 of the 2,750 cases (4.6%). Chordoma was the most frequent tumour in the cervical and sacral regions, while the most common diagnosis overall was multiple myeloma and plasmacytoma. Osteosarcoma ranked third. The mean age of presentation was 42 years and pain was the most common presenting symptom, occurring in 95% of malignant and 76% of benign tumours. Neurological involvement occurred in 52% of malignant tumours and usually meant a poor prognosis. The establishment of Bone Tumour Registries is the only way that sufficient data on large numbers of these rare tumours can be accumulated to provide a valuable and otherwise unavailable source of information for research, education and clinical follow-up.


Tumour Spine Registry 


  1. 1.
    Barwick KW, Havus AG, Smith J (1980) Primary osteogenic sarcoma of the vertebral column: a clinicopathologic correlation in ten patients. Cancer 36:595–604CrossRefGoogle Scholar
  2. 2.
    Blackwell JB, Threlfall TJ, McCaul KA (2005) Primary malignant bone tumours in Western Australia, 1972–1996. Pathology 37(4):278–283PubMedCrossRefGoogle Scholar
  3. 3.
    Bohlman HH, Sachs BL, Carter JR, Riley L, Robinson RA (1986) Primary neoplasms of the cervical spine: diagnosis and treatment of 23 patients. J Bone Joint Surg 86A:483–494Google Scholar
  4. 4.
    Dahlin DC (1978) Bone tumours: general aspects and data on 6,221 cases, 3rd edn. Charles C Thomas, SpringfieldGoogle Scholar
  5. 5.
    Dilorenzo N, Guiffe H, Fortuna E (1982) Primary spinal neoplasms in childhood: analysis of 1234 published cases (including 56 personal cases) by pathology, sex, age and site: Differences from the situation in adults. Neurochirugia 25:153–164Google Scholar
  6. 6.
    Dreghorn CR, Newman RJ, Hardy GJ, Dickson RA (1990) Primary tumours of the axial skeleton. Experience of the Leeds regional tumour registry. Spine 15:137–140PubMedCrossRefGoogle Scholar
  7. 7.
    Friedlaender GE, Southwick WO (1982) Tumours of the spine. In: Rothman RH, Simone FA (eds) The spine. WB Saunders & Co, Philadelphia, pp 1022–1040Google Scholar
  8. 8.
    Hay M, Paterson D, Taylor T (1978) Aneurysmal bone cysts of the spine. J Bone Joint Surg 60-B:406–411Google Scholar
  9. 9.
    Larsson S-E, Lorentzon R (1974) The incidence of malignant primary bone tumours in relation to age, sex and site: a study of osteogenic sarcoma, chondrosarcoma and Ewing’s sarcoma diagnosed in Sweden from 1958 to 1968. J Bone Joint Surg 56B:534–540Google Scholar
  10. 10.
    Limb D, Dreghorn C, Murphy JK, Mannion R (1994). Primary lymphoma of bone. Int Orthop 18:180–183PubMedCrossRefGoogle Scholar
  11. 11.
    Liu ZJ, Shiao LY, Huang CD (1982) Analysis of pathological statistics on 1900 cases of bone tumours and tumour-like lesions. Clin J Orthop 1:15–21Google Scholar
  12. 12.
    Luck JV, Monsen DCG (1970) Bone tumours and tumour-like lesions of vertebrae. In: Ruge D, Wiltse LL (eds) Spinal disorders: diagnosis and treatment. Lea and Febiger, Philadelphia, pp 274–286Google Scholar
  13. 13.
    Makley JT, Cohen AM, Boada E (1982) Sacral tumours: a hidden problem. Orthopaedics 5:996–1003Google Scholar
  14. 14.
    Maclellan DI, Wilson FA (1987) Osteoid osteoma of the spine. J Bone Joint Surg 49A:111–121Google Scholar
  15. 15.
    Mankin HJ, Mankine CJ, Simon MA (1996) The hazards of the biopsy, revisited. J Bone Joint Surg 78-A:656–663Google Scholar
  16. 16.
    McMaster ML, Goldstein AM, Bromley CM, Ishibe N, Parry DM (2001) Chordoma: incidence and survival patterns in the United States, 1973–1995. Cancer Causes Control 12:1–11PubMedCrossRefGoogle Scholar
  17. 17.
    Price CHG, Jeffree GM (1977) Incidence of bone sarcoma in SW England 1946–74, in relation to age, sex, tumour site and histology. Br J Cancer 36:511–522PubMedGoogle Scholar
  18. 18.
    Schajowicz F (1981) Tumours and tumour-like lesions of bone and joints. Springer, Berlin Heidelberg New YorkGoogle Scholar
  19. 19.
    Schajowicz F, Araujo EHS (1983) Cysts and tumours of the musculo-skeletal system: Pathology. In: Harris NH (ed) Postgraduate textbook of clinical orthopaedics. Wright PSJ, Briston, pp 605–639Google Scholar
  20. 20.
    Schajowicz F, Lemos C (1976) Malignant osteoblastoma. J Bone Joint Surg 58B:202–211Google Scholar
  21. 21.
    Triche T, Gavazzana A (1988) Bone tumours. In: Unni KK (ed) Contemporary issues in surgical pathology, vol 11. Edinburgh, Churchill LivingstoneGoogle Scholar
  22. 22.
    Weinstein JN, Maclain RF (1987) Primary tumours of the spine. Spine 12:843–851PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Simon P. Kelley
    • 1
    • 2
  • Robert U. Ashford
    • 1
  • Abhay S. Rao
    • 1
  • Robert A. Dickson
    • 1
  1. 1.Department of Orthopaedic Surgery, St. James’s University HospitalLeeds Teaching Hospitals NHS TrustLeedsUK
  2. 2.BristolUK

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