Prediction of Distributions of Amino Acids and Amino Acid Pairs in Human Haemoglobin α-Chain and its Seven Variants Causing α-Thalassaemia from their Occurrences According to the Random Mechanism

Abstract:

The probabilities of distributions of amino acids and amino acid pairs in normal human haemoglobin α-chain and its seven variants causing α-thalassaemia were studied to elicit the randomness of their positioning. The results show that 47.37% of distributions of amino acids conform to a simple random distribution and the distributions of the remaining amino acids are very near to a simple random distribution. However, variants of these patterns lead to nine distribution probabilities to increase and thus to occur more often, one distribution probability slightly decreases but its rank with respect to its distribution probability is unchanged and four distribution probabilities to decrease and thus occur less often among 14 distribution probabilities there being the least random in occurence. The decreased distribution probabilities in variants are exclusively related to leucine.