Skip to main content
SpringerLink
Log in

Toxicity effects of mercury and silver nanoparticles on common carp (Cyprinus carpio)

  • Original Article
  • Published:
Comparative Clinical Pathology Aims and scope Submit manuscript

Abstract

The purpose of this study was to investigate the toxic effects of mercury (Hg) and silver nanoparticles (AgNP) on histopathologic damage, mercury accumulation, and behavior pattern of common carp (Cyprinus carpio). In this regard, the fish were divided into six groups of Hg (one concentration), AgNPs (two concentrations), and Hg + AgNPs mixture (two concentrations) and one control group. Histopathological anomalies of various tissues of common carp was investigated using hematoxylin-eosin method. In this study, some histopathological changes in the intestine of carp such as degeneration, hemorrhage, increase in the number of goblet cells, and necrosis in the chemicals tested during different periods are observed. Moreover, results showed that the mercury uptake in tissues of common carp was increased in the presence of silver nanoparticles, so that the highest uptake of mercury in tissues was in gill tissues. In conclusion, the results indicated that the silver nanoparticles enhanced the toxicity and uptake of mercury in tissues of carp.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  • Aerle RV, Lange A, Moorhouse A, Paszkiewicz K, Ball K, Johnston BD (2013) Molecular mechanisms of toxicity of silver nanoparticles in zebrafish embryos. Environ Sci Technol 47:8005–8014

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Baker C, Pradhan A, Pakstis L, Pochan DJ, Shah S (2005) Synthesis and antibacterial properties of silver nanoparticles. J Nanosci Nanotechnol 5:244–249

    Article  CAS  PubMed  Google Scholar 

  • Blinova I, Niskanen J, Kajankari P, Kanarbik L, Käkinen A, Tenhu H (2013) Toxicity of two types of silver nanoparticles to aquatic crustaceans Daphnia magna and Thamnocephalus platyurus. Environ Sci Pollut Res 20:3456–3463

    Article  CAS  Google Scholar 

  • Carrasson M, Grau A, Dopazo LR, Crespo S (2006) A histological, histochemical and ultrastructural study of the digestive tract of Dentex dentex (Pisces, Sparidae). Histol Histopathol 21:579–593

    CAS  PubMed  Google Scholar 

  • Fan Y, Liu Z, Wang L, Zhan J (2009) Synthesis of starch-stabilized Ag nanoparticles and Hg2+ recognition in aqueous media. Nanoscale Res Lett 4:1230–1235

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fathi M, Binkowski LA, Azadi NA, Hamesadeghi U, Mansouri B (2018) Co-exposure effects of mercury chloride (HgCl2) and silver nanoparticles (Ag-NPs) on goldfish (Carassius auratus): histopathological changes, oxidative stress response, and bioaccumulation. Desalin Water Treat 105:264–272

    Article  CAS  Google Scholar 

  • Federici G, Shaw BJ, Handy RD (2007) Toxicity of titanium dioxide nanoparticles to rainbow trout (oncorhynchus mykiss): gill injury, oxidative stress, and other physiological effects. Aquat Toxicol 84:415–430

    Article  CAS  PubMed  Google Scholar 

  • Garnero PL, Monferran M, Gonzalez GA, Griboff J, de los Angeles BM (2018) Assessment of exposure to metals, As, and Se in water and sediment of a freshwater reservoir and their bioaccumulation in fish species of different feeding and habitat preferences. Ecotoxicol Environ Saf 163:492–501

    Article  CAS  PubMed  Google Scholar 

  • Georgieva E, Stoyanova S, Velcheva I, Vasileva T, Bivolarski V, Iliev L, Yancheva V (2014) Metal effects on histological and biochemical parameters of common rudd (Scardinius erythrophthalmus L.). Arch Pol Fish 22:197–206

    Article  CAS  Google Scholar 

  • Griffitt RJ, Brown-Peterson NJ, Savin D, Manning CS, Boube I, Ryan RA (2012) Effects of chronic nanoparticulate silver exposure to adult and juvenile Sheepshead minnows (Cyprinodon variegatus). Environ Toxicol Chem 31:160–167

    Article  CAS  PubMed  Google Scholar 

  • Kaya H, Aydın F, Gürkan M, Yılmaz S, Ates M, Demir V, Arslan Z (2016) A comparative toxicity study between small and large size zinc oxide nanoparticles in tilapia (Oreochromis niloticus): organ pathologies, osmoregulatory responses and immunological parameters. Chemosphere 144:571–582

    Article  CAS  PubMed  Google Scholar 

  • Kumar M, Puri A (2012) A review of permissible limits of water. Indian J Occup Environ Med 16(1):40–44

    Article  PubMed  PubMed Central  Google Scholar 

  • Liu L, Fan W, Lu H, Xiao W (2015) Effects of the interaction between TiO2 with different percentages of exposed 001 facets and Cu2+ on biotoxicity in Daphnia magna. Sci Rep 5:11121–11130

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Majnoni F, Mansouri B, Rezaei MR, Hamidian AH (2013) Contaminations of metals in tissues of common carp, Cyprinus carpio and silver carp, Hypophthalmichthys molitrix from Zarivar wetland, western Iran. Arch Pol Fish 21:11–18

    Article  CAS  Google Scholar 

  • Mansouri B, Ebrahimpour M, Babaei H (2012a) Bioaccumulation and elimination of nickel in the organs of black fish (Capoeta fusca). Toxicol Ind Health 28:361–368

    Article  CAS  PubMed  Google Scholar 

  • Mansouri B, Baramaki R, Ebrahimpour M (2012b) Acute toxicity bioassay of mercury and silver on Capoeta fusca (black fish). Toxicol Ind Health 28:393–398

    Article  CAS  PubMed  Google Scholar 

  • Mansouri B, Maleki A, Johari SA, Shahmoradi B, Mohammadi E, Shahsavari S, Davari B (2016a) Histopathological effects following short-term co-exposure to TiO2 and CuO nanoparticles in common carp (Cyprinus carpio). Environ Monit Assess 188:575–582

    Article  CAS  PubMed  Google Scholar 

  • Mansouri B, Maleki A, Johari S, Shahmoradi B, Mohammadi E, Shahsavari S, Davari B (2016b) Copper bioaccumulation and depuration in common carp (Cyprinus carpio) following co-exposure to TiO2 and CuO nanoparticles. Arch Environ Contam Toxicol 71:541–552

    Article  CAS  PubMed  Google Scholar 

  • Mansouri B, Maleki A, Johari SA, Shahmoradi B, Mohammadi E, Shahsavari S, Davari B (2017) Co-exposure effects of TiO2 and CuO nanoparticles on the gill and intestine histopathology of common carp (Cyprinus carpio). Chem Ecol 33:1–14

    Article  CAS  Google Scholar 

  • Martínez-Salcido AI, Ruelas-Inzunza J, Gil-Manrique B, Nateras-Ramírez O, Amezcua F (2018) Mercury levels in fish for human consumption from the southeast gulf of California: tissue distribution and health risk assessment. Arch Environ Contam Toxicol 74:273–283

    Article  CAS  PubMed  Google Scholar 

  • Mattsson K, Ekvall MT, Hansson L, Linse S, Malmendal A, Cedervall T (2015) Altered behavior, physiology, and metabolism in fish exposed to polystyrene nanoparticles. Environ Sci Technol 49:553–561

    Article  CAS  PubMed  Google Scholar 

  • Morris T, Copeland H, McLinden E, Wilson S, Szulczewski G (2002) The effects of mercury adsorption on the optical response of size-selected gold and silver nanoparticles. Langmuir 18:7261–7264

    Article  CAS  Google Scholar 

  • Pirsaheb M, Azadi NA, Miglietta ML, Sayadi MH, Blahova J, Fathi M, Mansouri B (2019) Toxicological effects of transition metal-doped titanium dioxide nanoparticles on goldfish (Carassius auratus) and common carp (Cyprinus carpio). Chemosphere 215:904–915

    Article  CAS  PubMed  Google Scholar 

  • Shahzad K, Khan MN, Jabeen F, Kosour N, Chaudhry AS, Sohail M (2018) Evaluating toxicity of copper(II) oxide nanoparticles (CuO-NPs) through waterborne exposure to tilapia (Oreochromis mossambicus) by tissue accumulation, oxidative stress, histopathology, and genotoxicity. Environ Sci Pollut Res Int 25:15943–15953

    Article  CAS  PubMed  Google Scholar 

  • Suganthi P, Murali M, Sadiq Bukhari A, Syed Mohamed HE, Basu H, Singhal RK (2015) Behavioural and histological variations in Oreochromis mossambicus after exposure to ZnO nanoparticles. Int J Appl Res 1:524–531

    Google Scholar 

  • Sumesh E, Bootharaju MS, Anshup T, Pradeep T (2011) A practical silver nanoparticle-based adsorbent for the removal of Hg2+ from water. J Hazard Mater 189:450–457

    Article  CAS  PubMed  Google Scholar 

  • Sun H, Zhang X, Niu Q, Chen Y, Crittenden JC (2007) Enhanced accumulation of arsenate in carp in the presence of titanium dioxide nanoparticles. Water Air Soil Pollut 178:245–254

    Article  CAS  Google Scholar 

  • Wu Y, Zhou Q (2013) Silver nanoparticles cause oxidative damage and histological changes in medaka (Oryzias latipes) after 14 days of exposure. Environ Toxicol Chem 32:165–173

    Article  CAS  PubMed  Google Scholar 

  • Zhang X, Sun H, Zhang Z, Niu Q, Chen Y, Crittenden JC (2007) Enhanced bioaccumulation of cadmium in carp in the presence of titanium dioxide nanoparticles. Chemosphere 67:160–166

    Article  CAS  PubMed  Google Scholar 

  • Zou X, Shi J, Zhang H (2014) Coexistence of silver and titanium dioxide nanoparticles: enhancing or reducing environmental risks? Aquat Toxicol 154:168–175

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

The authors would like to thank everyone at the Health Department laboratory who helped with the analyses and providing the reference fish.

Author information

Authors and Affiliations

  1. Environmental Health Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran

    Raouf Rahmani

  2. Kurdistan University of Medical Sciences, Sanandaj, Iran

    Younes Hamesadeghi

  3. Young Researchers and Elite Club, Kermanshah Branch Islamic Azad University, Kermanshah, Iran

    Ali Mansouri

Authors
  1. Raouf Rahmani
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Younes Hamesadeghi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ali Mansouri
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

Conceived and designed the experiments: A.M., and Y.H. Performed the experiments: Y.H., and R.R. Analyzed the data: A.M., and R.R. Wrote the paper: A.M., Y.H., and R.R. All authors revised and approved manuscript submission.

Corresponding author

Correspondence to Ali Mansouri.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Ethic approval

All institutional and national guidelines for the care and use of laboratory animals were followed.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Rahmani, R., Hamesadeghi, Y. & Mansouri, A. Toxicity effects of mercury and silver nanoparticles on common carp (Cyprinus carpio). Comp Clin Pathol 28, 811–816 (2019). https://doi.org/10.1007/s00580-019-02933-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00580-019-02933-y

Keywords

Search

Navigation