Impairment of neuro-renal cells on exposure to cosmopolitan polluted river water followed by differential protection of Launea taraxacifolia in male rats

  • J. K. AkintundeEmail author
  • M. T. Woleola
Original Article


Neuron-nephron toxicity (NNT) has been associated with the development of Alzheimer’s disease and mental disorders. We hypothesized that increased neuronal cholinesterase activities and oxidative stress play significant roles in kidney injury and that methanolic fraction from Launea taraxacifolia (LTME) could differentially promote brain-kidney wellness after sub-chronic exposure to metropolitan Surulere polluted river water (SPRW). The animals were divided into six groups (n = 8). Group I was orally given 1 ml of distilled water only; group II received 1 ml of SPRW only; group III (pre-treated) received 200 mg/kg LTME before + 1 ml of SPRW after; group IV (Co-treated) received 200 mg/kg LTME + 1 ml of SPRW; group V (post-treated) received 1 ml of SPRW before + 200 mg/kg LTME after; and group VI received 200 mg/kg LTME only. The experiment lasted for 28 days. Exposed animals to SPRW exhibited impairment to neuronal and nephritic cells with elevated cholinesterase activities and significant (p < 0.05) alteration in cerebral and renal antioxidants. There was also brain-kidney depletion in lactate dehydrogenase (LDH) activity. Differential treatment from LTME prevented the sub-chronic SPRW intoxication in brain-kidney of male rat. Conclusively, LTME differentially attenuates the key indicators of neuron-nephritis and restores the endogenous antioxidant molecules via reduction of AChE and BuChE activities.


Methanolic Launea taraxacifolia Surulere river water Differential treatment Neuron-nephron interaction Cholinesterase activities 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval involving animals

All applicable international, national, and/or institutional guidelines for the care and use of animals were followed. Specifically, animal care and handling was performed according to the institutional guidelines for the protection of animal welfare during experiments.


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Authors and Affiliations

  1. 1.Applied Biochemistry and Molecular Toxicology Research Group, Department of Biochemistry, College of BiosciencesFederal University of AgricultureAbeokutaNigeria
  2. 2.Department of Biochemistry, Faculty of Basic Medical Sciences, College of Pure and Applied SciencesKwara State UniversityMaleteNigeria

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