Comparative Clinical Pathology

, Volume 28, Issue 5, pp 1237–1244 | Cite as

Antioxidant effects of Allium cepa and cinnamon on biochemical parameters and ultrastructure of ovarian tissue in extremely low frequency electromagnetic field exposed rats

  • Arash KhakiEmail author
  • Elham Mansouri
Original Article


We investigated whether 50 Hz wave (3 mT) extremely low frequency electromagnetic field (ELF-EMF) had effect on ovarian tissue biochemical parameters and whether Allium cepa and cinnamon can reduce potential adverse effects of electromagnetic exposure. Forty female Wistar rats were subdivided into four groups; (1) a control group received 3 cc normal saline (0.9%) daily and was treated for 6 weeks, (2) a group exposed to ELF-EMF of 3 mT for 4 h/day 7 days/week for 6 weeks, (3) a group received Allium cepa and cinnamon (75 mg/kg body weight) daily for 6 weeks, (4) and a group exposed to ELF-EMF and received Allium cepa and cinnamon. On the 42nd day of research, 5 cc blood was collected from all the rats to measure serum malondialdehyde (MDA) levels, glutathione peroxidase (GPX), superoxide dismutase (SOD), and catalase (CAT). Right ovaries were removed and prepared for electron microscopy study. Level of MDA significantly increased in the second group exposed to ELF-EMF (P < 0.05) and decreased in groups that received of Allium cepa and cinnamon (75 mg/kg body weight) (P < 0.05) in comparison to the control group. As well, levels of SOD, GPX, and CAT, significantly decreased in the second group (P < 0.05) and increased in groups that received Allium cepa and cinnamon (P < 0.05). Using Allium cepa and cinnamon as a nutritional supplements has beneficial effects on protection of reproductive systems in this life area population exposed to electromagnetic field.


Antioxidants Allium cepa Cinnamon zeylanicum Electromagnetic field Ovary 



We gratefully thank Tabriz University of Medical Sciences for their help.


This study receives financial support from Tabriz University of Medical Sciences with grant number 93/2-4/9.

Compliance with ethical standards

Disclosure of potential conflict of interest

The authors declare that they have no conflict of interest.

Research involving animals

The animals were kept, administered and sacrificed based on declarations of Helsinki as well as website The protocol is approved by the ethic committee of Tabriz University of Medical Sciences with code 9315.

Informed consent

Not applicable.


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Copyright information

© Springer-Verlag London Ltd., part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Pathology, Tabriz BranchIslamic Azad UniversityTabrizIran
  2. 2.Department of Medical Physics, School of MedicineTabriz University of Medical SciencesTabrizIran

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