The central role of ATP in controlling broiler’s food intake

  • Sahel MotaghiEmail author
  • Hossein Jonaidi
  • Samaneh Noori Gooshki
  • Alireza Bashiri
Original Article


Purine nucleotides play different roles in many physiological functions of the central nervous system. The aim of this study was to investigate the effect of the central purine molecule ATP, an agonist of P2 receptors, for the first time, in the regulation of feeding behavior in broilers. Different doses of ATP (2.5, 25, and 50 μg) and its antagonist pyridoxal-phosphate-6-azophenyl-2′, 4′-disulphonic acid (PPADS) (50 μg), ATP (50 μg) plus PPADS (50 μg), and the solvent were injected intracerebroventricularly (ICV) to broilers. ATP increased food intake. PPADS reduced food intake. Concurrent injection of ATP and PPADS reduced food intake too. The present study suggests that ATP and P2 receptors are included in the regulation of food intake in neonate birds.


ATP Broilers Food intake P2 receptors 


Funding information

This research was financially supported by Shahid Bahonar University of Kerman Research Council under annual grant of corresponding author (No. 1393).

Compliance with ethical standards

Ethical approval

All applicable international, national, and/or institutional guidelines for the care and use of animals were followed. All procedures performed in this study involving animals were in accordance with the ethical standards of the institution at which the studies were conducted.

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag London Ltd., part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Basic Sciences, Faculty of Veterinary MedicineShahid Bahonar University of Kerman (SBUK)KermanIran
  2. 2.Department of Clinical Sciences, Faculty of Veterinary MedicineUniversity of TehranTehranIran

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