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Hemodynamic premises of endothelial dysfunction in young patients with vertebrobasilar insufficiency

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Abstract

According to current interpretations, tonal regulation of major arteries is determined by the degree of endothelial function. Shear stress influence on the vascular endothelium is an important part of vascular physiology. The aim of this study was to evaluate endothelial dysfunction, dependent up on the stage of spondylogenic vertebrobasilar insufficiency using the indicator ISD (systole-diastolic index) in young patients with degenerative-dystrophic lesions of cervical spine. Our results show that there is significant association between the status of the endothelial wall and hemodynamic changes (the growth of the systole-diastolic ratio leads to an increase in vasoconstriction factors in the blood). Raised ET-1 together with increase in ISD in patients with spondylogenic vertebrobasilar insufficiency reflects a hemodynamically dependent link to endothelial dysfunction.

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References

  1. Barakat AI (2008) Dragging along: the glycocalyx and vascular endothelial cell mechanotransduction. Circ Res 102:747–748

  2. Chrissobolis S, Miller AA, Drummond GR (2011) Oxidative stress and endothelial dysfunction in cerebrovascular disease. Front Biosci 16(1):1733–1745

  3. Gur AY, Lampl Y, Gross B et al (2007) A new scale for assessing patients with vertebrobasilar stroke-the Israeli Vertebrobasilar Stroke Scale (IVBSS): inter-rater reliability and concurrent validity. Clin Neurol Neurosurg 23:16–21

  4. Kaye V (2011) Vertebrobasilar stroke overview of vertebrobasilar stroke, Medscape, Mar: 11–19

  5. Lapach SN, Chubenko AV, Babich PN (2000) Statistical methods in biomedical studies using Excel Kiev

  6. Melkumyants AA, Balashov SA (2001) Role of endothelial cells deformability in control of arterial diameter by shear stress. J Vascular Res 38:11–17

  7. Nekrasova NO (2012a) The changes in the heart rate variability in young patients with vertebrogenic vertebrobasilar insufficiency(тези): abstract of the 16 EFNS congress of neurology. Stockholm, Sweden - September 8-11:231–232

  8. Nekrasova NO (2012b) The peculiarities of heart rate variability in young patients with vertebrogenic vertebrobasilar insufficiency. Abstract of the Black Sea Symposium for young scientists in biomedicine. Varna, Bulgaria - September 23-25:26–27

  9. Sitel AB, Nefyodov AY, Bakhtadze MA, Sidorskaya NV, Kolosov AV, Sysoev GV, Asfandiyarova EV (2006) Modern view of the problem of extravasal vertebral-basilar insufficiency. Manual Therapy (2):8–16

  10. Transcranial Doppler Sonography (TCD) in diagnosing the vertebrobasilar insufficiency. (2005) Djelilovic-Vranic, Jasminka Acta Informatica Medica; 13 (2): 55–58

  11. Vanhoutte PM (2009) Endothelial dysfunction: the first step toward coronary arteriosclerosis. Circ J 73(4):595–601

  12. Worthley LI, Holt AW (2000) Acute ischaemic stroke: part II. The vertebrobasilar circulation. Crit Care Resusc 2(2):140–145

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Author information

Correspondence to Nataliya Oleksandrivna Nekrasova.

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The authors declare that they have no conflict of interest.

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Informed consent was obtained from all individual participants included in the study.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Nekrasova, N.O., Gorbach, T.V., Grygorova, I.A. et al. Hemodynamic premises of endothelial dysfunction in young patients with vertebrobasilar insufficiency. Comp Clin Pathol 29, 43–46 (2020) doi:10.1007/s00580-018-2791-5

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Keywords

  • Spondylogenic vertebra-basilar insufficiency
  • Shear stress
  • Endothelial dysfunction