Hemodynamic premises of endothelial dysfunction in young patients with vertebrobasilar insufficiency
According to current interpretations, tonal regulation of major arteries is determined by the degree of endothelial function. Shear stress influence on the vascular endothelium is an important part of vascular physiology. The aim of this study was to evaluate endothelial dysfunction, dependent up on the stage of spondylogenic vertebrobasilar insufficiency using the indicator ISD (systole-diastolic index) in young patients with degenerative-dystrophic lesions of cervical spine. Our results show that there is significant association between the status of the endothelial wall and hemodynamic changes (the growth of the systole-diastolic ratio leads to an increase in vasoconstriction factors in the blood). Raised ET-1 together with increase in ISD in patients with spondylogenic vertebrobasilar insufficiency reflects a hemodynamically dependent link to endothelial dysfunction.
KeywordsSpondylogenic vertebra-basilar insufficiency Shear stress Endothelial dysfunction
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
Informed consent was obtained from all individual participants included in the study.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
- Gur AY, Lampl Y, Gross B et al (2007) A new scale for assessing patients with vertebrobasilar stroke-the Israeli Vertebrobasilar Stroke Scale (IVBSS): inter-rater reliability and concurrent validity. Clin Neurol Neurosurg 23:16–21Google Scholar
- Kaye V (2011) Vertebrobasilar stroke overview of vertebrobasilar stroke, Medscape, Mar: 11–19Google Scholar
- Lapach SN, Chubenko AV, Babich PN (2000) Statistical methods in biomedical studies using Excel KievGoogle Scholar
- Melkumyants AA, Balashov SA (2001) Role of endothelial cells deformability in control of arterial diameter by shear stress. J Vascular Res 38:11–17Google Scholar
- Nekrasova NO (2012a) The changes in the heart rate variability in young patients with vertebrogenic vertebrobasilar insufficiency(тези): abstract of the 16 EFNS congress of neurology. Stockholm, Sweden - September 8-11:231–232Google Scholar
- Nekrasova NO (2012b) The peculiarities of heart rate variability in young patients with vertebrogenic vertebrobasilar insufficiency. Abstract of the Black Sea Symposium for young scientists in biomedicine. Varna, Bulgaria - September 23-25:26–27Google Scholar
- Sitel AB, Nefyodov AY, Bakhtadze MA, Sidorskaya NV, Kolosov AV, Sysoev GV, Asfandiyarova EV (2006) Modern view of the problem of extravasal vertebral-basilar insufficiency. Manual Therapy (2):8–16Google Scholar
- Transcranial Doppler Sonography (TCD) in diagnosing the vertebrobasilar insufficiency. (2005) Djelilovic-Vranic, Jasminka Acta Informatica Medica; 13 (2): 55–58Google Scholar