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Level of cystatin C in functional thyroid disorders and its relation to GFR

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Abstract

Thyroid hormones affect the development and physiology of the kidneys. Hypothyroidism and hyperthyroidism affect glomerular filtration rate (GFR), tubular function, renal blood flow, and structure of the kidney. Cystatin C is a non-glycosylated neuroendocrine protein. It is freely filtered at the glomerulus and completely reabsorbed and catabolized by cells of tubules. Cystatin C levels, affected by the thyroid state, is being increased in hyperthyroidism and decreased in hypothyroidism. The current study was conducted on 66 patients of thyroid disorder and 21 healthy control subjects. Total T3, total T4, and TSH were measured by cobas e 411. Human Cystatin C was measured using ELISA kit based on sandwich enzyme-linked immunosorbent assay. Cystatin C was significantly increased in both total hyperthyroid and clinical hyperthyroid groups as compared to control (p < 0.001). eGFRCys C and eGFRCr-Cys C were significantly decreased in hyperthyroid and clinical hyperthyroid (p < 0.001). Cystatin C was significantly reduced in hypothyroid group and subgroups comparing to control group (p < 0.001, p < 0.001, and p = 0.004, respectively). As regard to eGFRCys C, it was significantly an overestimate clearance in hypothyroid group and subgroups when compared to normal subjects (p < 0.001, p < 0.001, and p = 0.002, respectively). Thyroid dysfunction affects cystatin C level as well as cystatin-based eGFR so it is not suitable in thyroid dysfunction specially in clinical dysfunction.

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Authors and Affiliations

  1. Department of clinical pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

    Elham Mohammad El-Metwally, Mona Abo-Bakr El-Hussiny & Azza Abdel-Baky El-Baiomy

  2. Department of Internal medicine, Faculty of Medicine, Mansoura University, Mansoura, Egypt

    Mohammed Shereif Abd-Elgawad

Authors
  1. Elham Mohammad El-Metwally
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  2. Mona Abo-Bakr El-Hussiny
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  3. Mohammed Shereif Abd-Elgawad
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  4. Azza Abdel-Baky El-Baiomy
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Corresponding author

Correspondence to Mona Abo-Bakr El-Hussiny.

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An informed consent was obtained from all person included in this study, and approval of the local ethics committee of Mansoura University was also obtained with reference cod R/17.03.120.

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This work was performed by self financial aid.

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The authors declare that they have no conflict of interest.

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El-Metwally, E.M., El-Hussiny, M.AB., Abd-Elgawad, M.S. et al. Level of cystatin C in functional thyroid disorders and its relation to GFR. Comp Clin Pathol 26, 1141–1147 (2017). https://doi.org/10.1007/s00580-017-2499-y

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  • DOI: https://doi.org/10.1007/s00580-017-2499-y

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