Comparative Clinical Pathology

, Volume 26, Issue 2, pp 315–320 | Cite as

Effects of glutamine and glutamate supplementation in dogs with hemorrhagic enteritis

  • A.K.S. Rodrigues
  • G.B. Silva
  • T.L.A.C. Almeida
  • N. M. Borba
  • H.E.C.C. Cordeiro Manso
  • H.C. Manso Filho
Review Article


This study evaluated the effect of glutamine and glutamate supplementation on hematological and biochemical biomarkers in dogs with clinical enteritis. Fifteen young dogs (3–10 months) with clinical enteritis were divided into two groups: group 1 (G-CON)—five animals subjected to medical treatment without supplementation and group 2 (G-GLN)—ten animals subjected to medical treatment and orally supplemented with 0.5 g/Kg per day of a glutamine and glutamate for 14 days. The following variables were measured: blood count, plasma glutamine and glutamate, total plasma protein (TPP), albumin, globulin, urea, creatinine, aspartate aminotransferase (AST), alanine aminotransferase (ALT), cholesterol, and triglycerides. Supplementation increased the concentrations of GLN, PPT, globulin, albumin, urea, and triglycerides (P < 0.05). Erythrocyte count, hemoglobin concentration, hematocrit, red blood indices, and platelet count were not affected by supplementation. There were significant elevations in total white blood cells, neutrophils, and lymphocytes (P < 0.05) after supplementation, but other variables were not significantly different. A mixture of Gln + Glu along with drug treatment was therefore capable of producing elevations in immune cells (leukocytes and lymphocytes) and biomarkers associated with improved protein metabolism and health that favor recovery of the animals without causing damage to renal and hepatic systems.


Amino acids Albumin Globulin Lymphocytes 



This study was funded by the National Scientific and Technological Development (CNPq) and wanted to thank Ajinomoto of Brazil (Sao Paulo-SP, Brazil) for AminoGut donation and also to Professor Dr. Malcolm Watford, Rutgers University, for his review and comments on this paper.

Compliance with ethical standards

The Committee on Ethics and Animal Welfare of UFRPE-CEUA authorized this research by protocol #23082.006184/2010.

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag London 2016

Authors and Affiliations

  • A.K.S. Rodrigues
    • 1
  • G.B. Silva
    • 1
  • T.L.A.C. Almeida
    • 1
  • N. M. Borba
    • 2
  • H.E.C.C. Cordeiro Manso
    • 1
  • H.C. Manso Filho
    • 1
  1. 1.Laboratório de Biologia Molecular Aplicada da Produção Animal (BIOPA), Departamento de ZootecniaUniversidade Federal Rural de PernambucoRecifeBrazil
  2. 2.Departamento de Medicina VeterináriaUniversidade Federal Rural de PernambucoRecifeBrazil

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