Comparative Clinical Pathology

, Volume 24, Issue 5, pp 985–988 | Cite as

Evaluation the effects of N-acetyl cysteine on pericardial adhesions in experimental rabbit models

  • Mehran Shahzamani
  • Kamran Ghods
  • Gholamreza Abedi
  • Peyman Shahzamani
  • Mahmood Mirhoseini
  • Maryam Motamedi
Original Article
First Online:
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Accepted:
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Abstract

Adhesions are one of the main causes of re-sternotomy complications. In this study, we evaluated the potential of N-acetyl cysteine irrigation in reducing or preventing pericardial adhesions after cardiac surgery in rabbits. Thirty rabbits were allocated randomly into two groups. Group C served as the control, and group N was the treatment group. After anaesthesia, sternotomy and opening a pericardial flap, the pericardial cavity was irrigated with 1 ml/kg saline (group C) or with 100 mg/kg of N-acetyl cysteine (group N). After 2 months, the sternum was re-opened and the site of operation evaluated for macroscopic and microscopic changes. Macroscopic evaluation revealed 40 % (n = 6) with grade 1, 46 % (n = 7) with grade 2, and 13.3 % (n = 3) with grade 3 adhesions in group C. In group N, there were 60 % (n = 9) with grade 0 (no adhesions) and 40 % (n = 6) with grade 1 adhesions. N-acetyl cysteine irrigation appears to significantly reduce macroscopic adhesions, and there was also a trend towards a reduced reaction microscopically; therefore, further studies are warranted.

Keywords

Pericardial adhesions Re-sternotomy surgery Anti-inflammatory agents N-acetyl cysteine 
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Copyright information

© Springer-Verlag London 2014

Authors and Affiliations

  • Mehran Shahzamani
    • 1
  • Kamran Ghods
    • 2
  • Gholamreza Abedi
    • 3
  • Peyman Shahzamani
    • 3
  • Mahmood Mirhoseini
    • 4
  • Maryam Motamedi
    • 5
  1. 1.Department of Cardiovascular SurgeryIsfahan University of Medical SciencesIsfahanIran
  2. 2.Department of Cardiovascular SurgerySemnan University of Medical SciencesSemnanIran
  3. 3.Department of Clinical Sciences, Science and Research BranchIslamic Azad UniversityTehranIran
  4. 4.Department of Cardiovascular Surgery, Shaheed Modarres HospitalShaheed Beheshti University of Medical SciencesTehranIran
  5. 5.Faculty of MedicineNajafabad Azad UniversityIsfahanIran

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