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Comparative Clinical Pathology

, Volume 21, Issue 5, pp 681–685 | Cite as

Evaluation of prophylactic and therapeutic effects of silymarin on mebendazole-induced hepatotoxicity in cats

  • Bahman Mosallanejad
  • Reza Avizeh
  • Hossein Najafzadeh Varzi
  • Mehdi Pourmehdi
Original Article

Abstract

The aim of this study was to determine the protective action of silymarin on mebendazole-induced hepatotoxicity in cats. Twenty five healthy cats were randomly allotted into five equal groups. Cats in group A were given mebendazole (single dose 200 mg⁄kg, p.o.); group B consisted of cats that received silymarin (single dose 30 mg⁄kg, p.o.) concurrent with mebendazole administration; groups C, D and E were treated as group B, but silymarin was administered 2, 12 and 24 h after mebendazole administration, respectively. The serum concentrations of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and total and direct bilirubin were measured before mebendazole administration and 2, 12, 24 and 72 h later as indices of liver injury. A single oral administration of mebendazole significantly elevated serum concentrations of ALT, AST, ALP, LDH (in all cases), and total and direct bilirubin in one cat in group A, after 24 h (P < 0.05). In groups B and C, levels of serum enzyme activities and total and direct bilirubin remained within normal values, but in group D, levels of serum enzyme activity (in four cases) were higher than normal values and total and direct bilirubin remained within the normal range. In group E, levels of serum enzyme activities (in all cats) and total and direct bilirubin (in one cat) were higher than normal values. In conclusion, silymarin can protect liver tissue against oxidative stress in cats with mebendazole intoxication particularly in the first 2 h after exposure.

Keywords

Silymarin Hepatotoxicity Mebendazole Cat 

Notes

Acknowledgment

The authors wish to express their gratitude to the research council of Shahid Chamran University of Ahvaz for their financial support.

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Copyright information

© Springer-Verlag London Limited 2011

Authors and Affiliations

  • Bahman Mosallanejad
    • 1
  • Reza Avizeh
    • 1
  • Hossein Najafzadeh Varzi
    • 2
  • Mehdi Pourmehdi
    • 3
  1. 1.Department of Clinical Sciences, Faculty of Veterinary MedicineShahid Chamran University of AhvazAhvazIran
  2. 2.Department of Pharmacology and Toxicology, Faculty of Veterinary MedicineShahid Chamran University of AhvazAhvazIran
  3. 3.Department of Food Hygiene, Faculty of Veterinary MedicineShahid Chamran University of AhvazAhvazIran

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