Comparative Clinical Pathology

, Volume 20, Issue 2, pp 183–186 | Cite as

Reactivation of latent Toxoplasma gondii in immunocompromised cancer patients

  • Mohamad Nidal Khabaz
  • Layla Elkhateeb
  • Jamil Al-Alami
Original Article


Active Toxoplasma gondii infection in cancer patients undergoing anticancer chemotherapy was evaluated using both enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR) techniques. Ninety-nine cancer patients were studied. Sixty seven of those patients were under cancer chemotherapy treatment, 41 (61.2%) of which were found to be ELISA immunoglobulin g (IgG) positive and five (7.5%) were PCR positive. On the other hand, none of the 32 untreated cancer patients was found to be PCR positive although 22 (68.7%) of them were ELISA IgG positive. These findings suggest the possibility that treatment with immunosuppressive agents predisposed cancer patients to reactivation of T. gondii infection.


Toxoplasma gondii parasitemia Immunocompromised cancer patients Chemotherapy 


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Copyright information

© Springer-Verlag London Limited 2010

Authors and Affiliations

  • Mohamad Nidal Khabaz
    • 1
  • Layla Elkhateeb
    • 2
  • Jamil Al-Alami
    • 3
  1. 1.Department of Pathology, Faculty of MedicineJordan University of Science and TechnologyIrbidJordan
  2. 2.Department of Medical Laboratory Sciences, Faculty of Health Allied sciencesJordan University of Science and TechnologyIrbidJordan
  3. 3.Department of Molecular GeneticsShafallah Medical Genetics CenterDohaQatar

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