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Comparative Clinical Pathology

, Volume 18, Issue 3, pp 211–216 | Cite as

Thyroid hormones and their correlations with serum glucose, beta hydroxybutyrate, nonesterified fatty acids, cholesterol, and lipoproteins of high-yielding dairy cows at different stages of lactation cycle

  • M. Mohebbi-Fani
  • S. NazifiEmail author
  • E. Rowghani
  • S. Bahrami
  • O. Jamshidi
Original Article

Abstract

The relationships between circulating thyroid hormones and serum glucose, beta hydroxybutyrate (BHB), nonesterified fatty acid (NEFA), cholesterol and lipoproteins of high-yielding dairy cows were studied in 125 adult Holsteins at various stages of lactation cycle: early (far-off) dry period (n = 24), late (close-up) dry period (n = 10), fresh cows (n = 22), early lactation (n = 13), mid-lactation (n = 27) and late lactation (n = 29). Decreased levels of thyroxin (T4) and triiodothyronine (T3) were noted in peripartum cows which were extended to mid- and late-lactation cows, respectively. In fresh cows, glucose showed correlations with T4 (r = 0.619, P < 0.01) and T3 (r = 0.627, P < 0.01). In the same cows there were correlations between T4 and BHB (r = 0.590, P < 0.01) and NEFA (r = 0.470, P < 0.01). In late dry cows, free thyroxin (fT4) showed correlations with triglyceride (TG) and very-low-density lipoprotein (VLDL; r = −0.638, P < 0.05). Pooled data of the various stages of lactation cycle revealed correlations between glucose and T4 (r = 0.20, P < 0.05), glucose and T3 (r = 0.395, P < 0.01), cholesterol and T3 (r = −0.201, P < 0.05), and free triiodothyronine (fT3) and high-density lipoprotein (HDL; r = 0.178, P < 0.05). It appears that the time and the pattern of changes and/or correlations of serum thyroid hormones and lipid fractions may vary among dairy cows and other animals.

Keywords

Thyroid hormones Glucose Beta hydroxybutyrate Nonesterified fatty acids Cholesterol Lipoproteins High-yielding dairy cows Lactation cycle 

Abbreviations

NEB

negative energy balance

BHB

beta hydroxybutyrate

NEFA

nonesterified fatty acid

T4

thyroxine

T3

triiodothyronine

fT4

free thyroxine

fT3

free triiodothyronine

TG

triglyceride

VLDL

very-low-density lipoprotein

HDL

high-density lipoprotein

LDL

low-density lipoprotein

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Copyright information

© Springer-Verlag London Limited 2008

Authors and Affiliations

  • M. Mohebbi-Fani
    • 1
  • S. Nazifi
    • 2
    Email author
  • E. Rowghani
    • 3
  • S. Bahrami
    • 4
  • O. Jamshidi
    • 4
  1. 1.Department of Animal Health Management, School of Veterinary MedicineShiraz UniversityShirazIran
  2. 2.Department of Clinical Studies, School of Veterinary MedicineShiraz UniversityShirazIran
  3. 3.Department of Animal Sciences, School of AgricultureShiraz UniversityShirazIran
  4. 4.School of Veterinary MedicineShiraz UniversityShirazIran

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