Salinomycin is an ionophore compound that may be used in sheep as growth promoter or to prevent coccidiosis in these species. There are some reports with respect to the poisoning of animals with this agent used in high concentration in feed by mistake. So, the purpose of this study was to examine the gross and histopathologic lesions due to salinomycin in sheep. Fifteen adult (4 to 5 years old) male Mehraban sheep were randomly divided into three equal groups and doses of 1, 2, and 4 mg/kg of salinomycin were administrated orally twice a day for 2 days. Five sheep died due to acute toxicosis within 72 h after administration of the drug. Postmortem examination revealed congestion and edema of skeletal muscles, swelling and hemorrhage in peripheral lymph nodes, hydrothorax, and hydropericardium, petechial hemorrhage in fat tissues of heart base, severe pulmonary congestion and edema, large pale kidney, and swelling of liver with mild to moderate yellowish appearance. Histopathologic examination showed pulmonary congestion and edema with hyalinized thrombi in some of capillaries, myocardial degeneration, and necrosis without any inflammatory reaction. Hepatocytes, renal tubules, sciatic nerves, and muscles were among other tissues that showed histologic changes.
Salinomycin toxicosis Pathologic lesions Sheep
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Barros CSL (1998) Poisoning for ionophores antibiotics. In: Riet-Correa F, Schild AL, Mendez MC (eds) Illness of ruminants and equines. University Publishing Company, UF Pel, Pelotas, pp 462–466Google Scholar
Bastianello SS, McGregor HL, Penrith ML, Fourie N (1996) A chronic cardiomyopathy in feedlot cattle attributed to toxic levels of salinomycin in the feed. J S Afr Vet Assoc 67:38–41PubMedGoogle Scholar
Bergen WG, Bates DB (1984) Ionophores: their effect on production efficiency and mode of action. J Anim Sci 58:1465–1483PubMedGoogle Scholar
Fahim M, delValle G, Pressman BC (1986) Comparison of the effects of the ionophore salinomycin and adrenaline on the haemodynamics and work efficiency of the dog heart. Cardiovas Res 20:145–152CrossRefGoogle Scholar
Galitzer SJ, Bartley EE, Oehme FW (1982) Preliminary studies on lasalocid toxicosis in cattle. Vet Hum Toxicol 24:406–409PubMedGoogle Scholar
Galitzer SJ, Kruckenberg SM, Kidd JR (1986a) Pathological changes associated with experimental lasalocid and monensin toxicosis in cattle. Am J Vet Res 47:2624–2626PubMedGoogle Scholar
Russell JB, Houlihan AJ (2003) Ionophore resistance of ruminal bacteria and its potential impact on human health. FEMS Microbiol Rev 27:65–74PubMedCrossRefGoogle Scholar
Schweitzer D, Kimberling C, Spraker T, Sterner FE, McChesney AE (1984) Accidental monensin sodium intoxication of feedlot cattle. J Am Vet Med Assoc 184:1273–1276PubMedGoogle Scholar
Van der Linde-Sipman JS, Van den Ingh T, Van Nes JJ, Verhagen H, Kersten JGTM, Benyen AC, Plekkringa R (1999) Salinomycin-induced polyneuropathy in cats. Morphologic and epidemiologic data. Vet Pathol 36:152–156PubMedCrossRefGoogle Scholar
Wilson JS (1980) Toxic myopathy in a dog associated with the presence of monensin in dry food. Can Vet J 21:30–31PubMedGoogle Scholar