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Comparative Clinical Pathology

, Volume 15, Issue 4, pp 215–219 | Cite as

A retrospective study of the therapeutic efficacy of doxycycline on concurrent canine ehrlichiosis and babesiosis in a veterinary hospital population

  • Anuchai Niwetpathomwat
Original Article

Abstract

Doxycycline has a well known broad spectrum activity against bacteria and rickettsia, as well as Ehrlichia spp. However, the use of doxycycline for the treatment of concurrent ehrlichiosis and babesiosis has rarely been evaluated, especially in veterinary hospital populations. A retrospective study of 70 canine ehrlichiosis and 12 canine babesiosis concurrent infections from Out Patient Department patients at Chulalongkorn Small Animal Teaching Hospital, admitted during 2001–2003, were studied. The results showed a complete curative effect of doxycycline on both canine ehrlichiosis and canine babesiosis concurrent infections. The red blood cell indices after treatment were significantly higher in canine ehrlichiosis (P < 0.05). The platelet cell counts after treatment were significantly higher in concurrent canine ehrlichiosis and babesiosis infections (P < 0.05). Doxycycline can be recommended as the drug of choice for both canine ehrlichiosis and canine babesiosis and concurrent infections of both conditions in veterinary hospitals.

Keywords

Doxycycline Canine ehrlichiosis Concurrent infection Canine babesiosis 

Notes

Acknowledgements

I would like to thank The Veterinary Diagnostic Laboratory and Chulalongkorn Small Animal Teaching Hospital, Faculty of Veterinary Science, Chulalongkorn University, for providing all the data for this study. Also, my thanks to Dr. Terry Heard for correcting the manuscript.

References

  1. Arsenault WG, Messick JB (2005) Acute granulocytic ehrlichiosis in a rottweiler. J Am Anim Hosp Assoc 41(5):323–326PubMedGoogle Scholar
  2. Davoust B, Keundjian A, Rous V et al (2005) Validation of chemoprevention of canine monocytic ehrlichiosis with doxycycline. Vet Microbiol 107(3–4):273–279Google Scholar
  3. Dumler JS, Barbet AF, Bekker CP et al (2001) Reorganization of genera in the families Rickettsiaceae and Anaplasmataceae in the order Rickettsiales; unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia, and Ehrlichia with Neorickettsia; description of six new species combinations; and designation of Ehrlichia equi and “HGE agent” as subjective synonyms of Ehrlichia phagocytophilum. Int J Syst Evol Microbiol 51:2145–2165PubMedGoogle Scholar
  4. Jain MC (1986) The dog: normal hematology with comments on response to disease. In: Jain MC (ed) Veterinary hematology, 4th edn. Lea & Febiger, Philadelphia, pp 103–125Google Scholar
  5. Macieira Dde B, Messick JB, Cerqueira Ade M et al (2005) Prevalence of Ehrlichia canis infection in thrombocytopenic dogs from Rio de Janeiro, Brazil. Vet Clin Pathol 34(1):44–48PubMedCrossRefGoogle Scholar
  6. Maurin M, Bakken JS, Dumler JS (2003) Antibiotic susceptibilities of Anaplasma (Ehrlichia) phagocytophilum strains from various geographic areas in the United States. Antimicrob Agents Chemother 47(1):413–415PubMedCrossRefGoogle Scholar
  7. Miyama T, Sakata Y, Shimada Y et al (2005) Epidemiological survey of Babesia gibsoni infection in dogs in eastern Japan. J Vet Med Sci 67(5):467–471PubMedCrossRefGoogle Scholar
  8. Niwetpathomwat A, Techangamsuwan S, Suvarnavibhaja S (2006) A retrospective study of the clinical hematology and biochemistry of canine ehrlichiosis in an animal hospital population in Bangkok, Thailand. Comp Clin Pathol 14:217–220CrossRefGoogle Scholar
  9. Rodriguez-Vivas RI, Albornoz RE, Bolio GM (2005) Ehrlichia canis in dogs in Yucatan, Mexico: seroprevalence, prevalence of infection and associated factors. Vet Parasitol 127(1):75–79PubMedCrossRefGoogle Scholar
  10. Sainz A, Tesouro MA, Amusategui I et al (2000) Prospective comparative study of 3 treatment protocols using doxycycline or imidocarb dipropionate in dogs with naturally occurring ehrlichiosis. J Vet Intern Med 14(2):134–139PubMedCrossRefGoogle Scholar
  11. Tvedten H (2004) Reference values. In: Willard MD, Tvedten H (eds) Small animal clinical diagnosis by laboratory methods, 4th edn. Elsevier, Missouri, pp 417–419Google Scholar
  12. Van Heerden J, Reyers F, Stewart CG (1983) Treatment and thrombocyte levels in experimentally induced canine ehrlichiosis and canine babesiosis. Onderstepoort J Vet Res 50(4):267–270PubMedGoogle Scholar
  13. Vercammen F, De Deken R, Maes L (1996) Prophylactic treatment of experimental canine babesiosis (Babesia canis) with doxycycline. Vet Parasitol 66(3–4):251–255PubMedCrossRefGoogle Scholar
  14. Wanamaker BP, Massey KL (2004) Antiinfective drugs; Tetracyclines. In: Wanamaker BP, Massey KL (eds) Applied pharmacology for the veterinary technician. Saunders, St. Louis, MO, pp 227–228Google Scholar
  15. Watanabe M, Okuda M, Tsuji M et al (2004) Seroepidemiological study of canine ehrlichial infections in Yamaguchi prefecture and surrounding areas of Japan. Vet Parasitol 124(1–2):101–107PubMedCrossRefGoogle Scholar
  16. Zandvliet MM, Teske E, Piek CJ (2004) Ehrlichia and Babesia infections in dogs in The Netherlands. Tijdschr Diergeneeskd 129(22):740–745PubMedGoogle Scholar

Copyright information

© Springer-Verlag London Limited 2006

Authors and Affiliations

  1. 1.Department of Veterinary Medicine, Faculty of Veterinary ScienceChulalongkorn UniversityBangkokThailand

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