A retrospective study of the therapeutic efficacy of doxycycline on concurrent canine ehrlichiosis and babesiosis in a veterinary hospital population
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Doxycycline has a well known broad spectrum activity against bacteria and rickettsia, as well as Ehrlichia spp. However, the use of doxycycline for the treatment of concurrent ehrlichiosis and babesiosis has rarely been evaluated, especially in veterinary hospital populations. A retrospective study of 70 canine ehrlichiosis and 12 canine babesiosis concurrent infections from Out Patient Department patients at Chulalongkorn Small Animal Teaching Hospital, admitted during 2001–2003, were studied. The results showed a complete curative effect of doxycycline on both canine ehrlichiosis and canine babesiosis concurrent infections. The red blood cell indices after treatment were significantly higher in canine ehrlichiosis (P < 0.05). The platelet cell counts after treatment were significantly higher in concurrent canine ehrlichiosis and babesiosis infections (P < 0.05). Doxycycline can be recommended as the drug of choice for both canine ehrlichiosis and canine babesiosis and concurrent infections of both conditions in veterinary hospitals.
KeywordsDoxycycline Canine ehrlichiosis Concurrent infection Canine babesiosis
I would like to thank The Veterinary Diagnostic Laboratory and Chulalongkorn Small Animal Teaching Hospital, Faculty of Veterinary Science, Chulalongkorn University, for providing all the data for this study. Also, my thanks to Dr. Terry Heard for correcting the manuscript.
- Davoust B, Keundjian A, Rous V et al (2005) Validation of chemoprevention of canine monocytic ehrlichiosis with doxycycline. Vet Microbiol 107(3–4):273–279Google Scholar
- Dumler JS, Barbet AF, Bekker CP et al (2001) Reorganization of genera in the families Rickettsiaceae and Anaplasmataceae in the order Rickettsiales; unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia, and Ehrlichia with Neorickettsia; description of six new species combinations; and designation of Ehrlichia equi and “HGE agent” as subjective synonyms of Ehrlichia phagocytophilum. Int J Syst Evol Microbiol 51:2145–2165PubMedGoogle Scholar
- Jain MC (1986) The dog: normal hematology with comments on response to disease. In: Jain MC (ed) Veterinary hematology, 4th edn. Lea & Febiger, Philadelphia, pp 103–125Google Scholar
- Tvedten H (2004) Reference values. In: Willard MD, Tvedten H (eds) Small animal clinical diagnosis by laboratory methods, 4th edn. Elsevier, Missouri, pp 417–419Google Scholar
- Wanamaker BP, Massey KL (2004) Antiinfective drugs; Tetracyclines. In: Wanamaker BP, Massey KL (eds) Applied pharmacology for the veterinary technician. Saunders, St. Louis, MO, pp 227–228Google Scholar