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Comparative Clinical Pathology

, Volume 13, Issue 2, pp 86–87 | Cite as

Serum angiotensin-converting enzyme activity is not a useful biomarker for canine splenic haemangiosarcoma

  • Robert M. JacobsEmail author
Short Paper
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Abstract

Serum angiotensin-converting enzyme (ACE) activity is derived normally from endothelial cells. It was hypothesised that serum ACE activity might be increased and serve as a biomarker in canine patients with endothelial cell cancer. Here, the serum ACE activity was determined in cases of canine splenic haemangiosarcoma (sHS, n=16), a relatively common malignant tumour of endothelial cells in dogs, and control dogs (n=29). There was no significant difference in serum ACE activity between these groups of dogs. Two of 16 dogs (13%) with sHS had serum ACE activities greater than any of the control dogs; however, the increases were slight. Serum ACE activity does not appear to be a useful biomarker for canine sHS.

Keywords

Canine Haemangiosarcoma Serum angiotensin-converting enzyme Spleen 

Notes

Acknowledgements

The technical assistance of Barbara Jefferson and Oliver Trochta was very much appreciated. The project was supported by the Pet Trust Fund of the Ontario Veterinary College, University of Guelph.

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Copyright information

© Springer-Verlag London Limited 2004

Authors and Affiliations

  1. 1.Department of PathobiologyUniversity of GuelphGuelphCanada

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