Comparative Clinical Pathology

, Volume 13, Issue 2, pp 86–87 | Cite as

Serum angiotensin-converting enzyme activity is not a useful biomarker for canine splenic haemangiosarcoma

  • Robert M. JacobsEmail author
Short Paper


Serum angiotensin-converting enzyme (ACE) activity is derived normally from endothelial cells. It was hypothesised that serum ACE activity might be increased and serve as a biomarker in canine patients with endothelial cell cancer. Here, the serum ACE activity was determined in cases of canine splenic haemangiosarcoma (sHS, n=16), a relatively common malignant tumour of endothelial cells in dogs, and control dogs (n=29). There was no significant difference in serum ACE activity between these groups of dogs. Two of 16 dogs (13%) with sHS had serum ACE activities greater than any of the control dogs; however, the increases were slight. Serum ACE activity does not appear to be a useful biomarker for canine sHS.


Canine Haemangiosarcoma Serum angiotensin-converting enzyme Spleen 



The technical assistance of Barbara Jefferson and Oliver Trochta was very much appreciated. The project was supported by the Pet Trust Fund of the Ontario Veterinary College, University of Guelph.


  1. Baudin B (2002) New aspects on angiotensin-converting enzyme: from gene to disease. Clin Chem Lab Med 40:256–265PubMedGoogle Scholar
  2. Beneteau-Burnat B, Baudin B (1991) Angiotensin-converting enzyme: clinical applications and laboratory investigations on serum and other biological fluids. Crit Rev Clin Lab Sci 28:337–356PubMedGoogle Scholar
  3. Caldwell PRB, Seegal BC, Hsu KC, et al (1976) Angiotensin converting enzyme: vascular endothelial localization. Science 191:1050–1051PubMedGoogle Scholar
  4. Cushman DW, Cheung HS (1971) Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung. Biochem Pharmacol 20:1637–1648Google Scholar
  5. Jensen AL, Koch J (1992) Determination of angiotensin converting enzyme in canine serum. Clin Chem Enzyme Comms 4:311–317Google Scholar
  6. Le Treut A, Couliou H, Delbary M et al (1979) Le dosage de l’enzyme de conversion de l’angiotensine I par methode spectrophotometrique. Clin Chim Acta 98:1–4CrossRefPubMedGoogle Scholar
  7. Siefkin AD, Parsons GH, Patwell SW, et al (1984) The value of serial serum angiotensin converting enzyme determinations in hospitalized patients with lung disease. Am J Med Sci 288:200–207PubMedGoogle Scholar

Copyright information

© Springer-Verlag London Limited 2004

Authors and Affiliations

  1. 1.Department of PathobiologyUniversity of GuelphGuelphCanada

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