Serum angiotensin-converting enzyme activity is not a useful biomarker for canine splenic haemangiosarcoma
- 30 Downloads
Serum angiotensin-converting enzyme (ACE) activity is derived normally from endothelial cells. It was hypothesised that serum ACE activity might be increased and serve as a biomarker in canine patients with endothelial cell cancer. Here, the serum ACE activity was determined in cases of canine splenic haemangiosarcoma (sHS, n=16), a relatively common malignant tumour of endothelial cells in dogs, and control dogs (n=29). There was no significant difference in serum ACE activity between these groups of dogs. Two of 16 dogs (13%) with sHS had serum ACE activities greater than any of the control dogs; however, the increases were slight. Serum ACE activity does not appear to be a useful biomarker for canine sHS.
KeywordsCanine Haemangiosarcoma Serum angiotensin-converting enzyme Spleen
The technical assistance of Barbara Jefferson and Oliver Trochta was very much appreciated. The project was supported by the Pet Trust Fund of the Ontario Veterinary College, University of Guelph.
- Cushman DW, Cheung HS (1971) Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung. Biochem Pharmacol 20:1637–1648Google Scholar
- Jensen AL, Koch J (1992) Determination of angiotensin converting enzyme in canine serum. Clin Chem Enzyme Comms 4:311–317Google Scholar