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Microsystem Technologies

, Volume 7, Issue 5–6, pp 265–268 | Cite as

Microfabrication of single-use plastic microfluidic devices for high-throughput screening and DNA analysis

  • A. Gerlach
  • G. Knebel
  • A.E. Guber
  • M. Heckele
  • D. Herrmann
  • A. Muslija
  • TH. Sshaller

Abstract

 Modern drug discovery and genomic analysis depend on rapid analysis of large numbers of samples in parallel. The applicability of microfluidic devices in this field needs low cost devices, which can be fabricated in mass production. In close collaboration, Greiner Bio-One and Forschungszentrum Karlsruhe have developed a single-use plastic microfluidic capillary electrophoresis (CE) array in the standardized microplate footprint. Feasibility studies have shown that hot embossing with a mechanical micromachined molding tool is the appropriate technology for low cost mass fabrication. A subsequent sealing of the microchannels allows sub-microliter sample volumes in 96-channel multiplexed microstructures.

Keywords

Capillary Electrophoresis Drug Discovery Mass Production Feasibility Study Microfluidic Device 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2002

Authors and Affiliations

  • A. Gerlach
    • 1
  • G. Knebel
    • 1
  • A.E. Guber
    • 2
  • M. Heckele
    • 2
  • D. Herrmann
    • 2
  • A. Muslija
    • 2
  • TH. Sshaller
    • 3
  1. 1.Greiner Bio-One GmbH, Maybachstrasse 2, 72636 Frickenhausen, Germany e-mail: a.gerlach@greinerbioone.comDE
  2. 2.Forschungszentrum Karlsruhe, Institut für Mikrostrukturtechnik, Postfach 3640, 76021 Karlsruhe, GermanyDE
  3. 3.Forschungszentrum Karlsruhe, Hauptabteilung Versuchstechnik, Postfach 3640, 76021 Karlsruhe, GermanyDE

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