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Microsystem Technologies

, Volume 24, Issue 8, pp 3371–3379 | Cite as

Design of MEMS sensor for the detection of cholera and diarrehea by capacitance modulation

  • K. V. Vineetha
  • P. Ashok Kumar
  • B. V. S. Sailaja
  • Koushik Guha
  • K. Girija Sravani
  • K. Srinivasa Rao
Technical Paper
  • 102 Downloads

Abstract

Cholera is caused by vibriocholera bacteria which were present in water or food. Diarrhea is caused by E. coli bacteria which were present in water or food. Bio-sensors were used for the detection of waterborne elements in the fluids. This, paper provides a bio-sensor for the detection of cholera and diarrehea which is present in the water using capacitive technique. The bio-sensor is designed using FEM tool. Two types of channel based bio-sensor was designed cylindrical based and rectangular based. A simulation is also performed with and without the presence of bacteria cells in water and resultant capacitance is also computed using FEM tool. The sensitivity of the device is also calculated with and without the presence of bacteria cells in the water. The flow velocity, flow rate of cylindrical and rectangular channels is performed using FEM tool.

Notes

Acknowledgements

The Authors would like to thank to NMDC supported by NPMASS, National Institute of Technology, Silchar for providing the necessary computational tools. The corresponding author (Dr. K. Srinivasa Rao) would like to thank Science Engineering Research Board (SERB), Govt. of India, New Delhi (Grant File No: ECRA/2016/000757) for providing partial financial assistance to carry out this work.

References

  1. Dwivedi AK et al (2010) Detection of E. coli cell using capacitance modulation. COMSOL users conference Bengaluru, IndiaGoogle Scholar
  2. Baker RM, Singleton FL, Hood MA (1983) Appl Environ Microbiol 46(4):930–940Google Scholar
  3. Bhowmick TS, Koley H, Das M, Saha DR, Sarkar BL (2009) J Antimicrob Agents 33:569–573CrossRefGoogle Scholar
  4. Blackstonea GM, Nordstroma JL, Bowenb MD, Meyerb RF, Imbroc P, DePaola A (2007) J Microbiol Methods 68(2):254–259CrossRefGoogle Scholar
  5. Colwell RR (2000) J Infect Chemother 6(2):121–125CrossRefGoogle Scholar
  6. Gau JJ et al (2001) A MEMS based amperometric detector for E. coli bacteria using self-assembled monolayers. Biosens Bioelectron 16:745–755CrossRefGoogle Scholar
  7. Gubala AJ (2006) J Microbiol Methods 65:278–293CrossRefGoogle Scholar
  8. Horvath R, Pedersen HC, Skivesen N (2003) Opt Lett 28:1233–1235CrossRefGoogle Scholar
  9. Jyoung JY, Hong S, Lee W, Choi JW (2006) Biosens Bioelectron 21:2315–2319CrossRefGoogle Scholar
  10. Kant L (2008) Combating emerging infectious diseases in India: orchestrating a symphony. J Biosci 33:425–427CrossRefGoogle Scholar
  11. Koch WH, Payne WL, Wentz BA, Cebula TA (1993) Appl Environ Microbiol 59(2):556–560Google Scholar
  12. Koubova V, Brynda E, Karasova L, Skvor J, Homola J (2001) Sens Actuators B 74:100–105CrossRefGoogle Scholar
  13. Lang HP, Hegner M, Meyer E, Gerber C (2002) Nanotechnology 13:R29–R36CrossRefGoogle Scholar
  14. Lang HP, Hegner M, Gerber C (2005) Mater Today 8(4):30–36CrossRefGoogle Scholar
  15. Liuand Y, Duan Y (2006) Encyclopaedia of sensors, vol 1. American Scientific Publishers, New York, pp 371–400Google Scholar
  16. Lkojiasami et al Dielectric analysis of Escherichia coli suspensions in the light of the theory of interfacial polarization. Institute for Chemical Research, Kyoto University, Uji, Kyoto-fu 611, JapanGoogle Scholar
  17. Louis VR, Estelle RC, Choopun N, Rivera ING, Gangle B, Jiang SC, Rubin A, Patz JA, Huq A, Colwell RR (2003) Appl Environ Microbiol 69(5):2773–2785CrossRefGoogle Scholar
  18. Lyon WJ (2001) Tag man PCR for detection of vibrio cholerae O1, O139, non-O1, and non-O139 in pure cultures, raw oysters, and synthetic sea water. Appl Environ Microbiol 67(10):4685–4693CrossRefGoogle Scholar
  19. Rao VK, Sharma MK, Goel AK, Singh L, Sekhar K (2006) Anal Sci 22:1207–1211CrossRefGoogle Scholar
  20. Rivera ING, Lipp EK, Gil A, Choopun N, Huq A, Colwell RR (2003) Environ Microbiol 5(7):599–606CrossRefGoogle Scholar
  21. Stender H et al (2001) Rapid detection, identification, and enumeration of Escherichia coli cells in municipal water by chemiluminescent in situ hybridization. Appl Environ Microbiol 67(1):9–10, 11, 142–147Google Scholar
  22. Thundat T, Wachter EA, Sharp SL, Warmack RJ (1995) Appl Phys Lett 66:1695–1697CrossRefGoogle Scholar
  23. Weber M, Yerino C, Montanaro H, Lo KSL, Reed M (2001) Multiphysics simulations enable development of fast, cheap MEMS-based bacteria detector. Winner of 2011 create the future design contest aims at reducing food-borne infectionsGoogle Scholar
  24. Yoh M, Miyagi K, Matsumoto Y, Hayashi K, Takarada Y, Yamamoto K, Honda T (1993) Development of an enzyme-labeled oligonucleotide probe for the cholera toxin gene. J Clin Microbiol 31(5):1312–1314Google Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.MEMS Research Center, Department of Electronics and Communication EngineeringKL UniversityGunturIndia
  2. 2.National MEMS Design Centre, Department of ECENational Institute of TechnologySilcharIndia

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