Microsystem Technologies

, Volume 20, Issue 7, pp 1249–1272

Overview of microneedle system: a third generation transdermal drug delivery approach

  • M. S. Giri Nandagopal
  • Rahul Antony
  • S. Rangabhashiyam
  • Nidhin Sreekumar
  • N. Selvaraju
Review Paper

DOI: 10.1007/s00542-014-2233-5

Cite this article as:
Giri Nandagopal, M.S., Antony, R., Rangabhashiyam, S. et al. Microsyst Technol (2014) 20: 1249. doi:10.1007/s00542-014-2233-5

Abstract

Transdermal drug delivery has given cardinal contribution to medical practices. First-generation transdermal delivery of small, lipophilic, low-dose drugs and second-generation delivery systems using chemical enhancers, non-cavitational ultrasound and iontophoresis have also resulted in various clinical products provides added functionality. Third-generation delivery systems using microneedles, thermal ablation, microdermabrasion, electroporation and cavitational ultrasound targeting skin’s barrier layer of stratum corneum. Microneedles acquire pronounced intrigue in recent days. Currently, microneedles are advancing through clinical trials for delivery of macromolecules and vaccines, such as insulin, parathyroid hormone and influenza vaccine. The review explains about the concept of transdermal drug microneedle system comprising of microreservoir, micropumps, flow sensors, types of microneedles. Various researches carried out on these components of microneedle system is elaborately discussed in this review.

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • M. S. Giri Nandagopal
    • 1
  • Rahul Antony
    • 1
  • S. Rangabhashiyam
    • 1
  • Nidhin Sreekumar
    • 1
  • N. Selvaraju
    • 1
  1. 1.Department of Chemical EngineeringNational Institute of Technology CalicutKozhikodeIndia

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