Microsystem Technologies

, Volume 16, Issue 11, pp 1893–1899 | Cite as

Biodegradable submicrometric sieves in PLLA fabricated by soft lithography

  • Luis Gutierrez-Rivera
  • Lucila Cescato
Technical Paper


Sieves are membranes with a regular array of uniform pores that present low flow resistance. Because of such characteristics they are promising devices for filtration, separation of particles by size and drug delivery control systems. In this paper, we propose and demonstrated the use of a soft lithography process for fabrication of biodegradable sieves in PLLA (poly-l-lactide) with pores in the scale of hundred of nanometers. The fabrication process is suitable for mass production and submicrometric pore diameters can be fabricated with homogeneity of about 15%. The PLLA self sustained sieve can be integrated to PLLA capsules, compounding a drug delivery systems or implants.


PDMS PLLA PDMS Mold PDMS Film Interference Lithography 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was supported by the Conselho Nacional de Desenvolvimento Cientifico e Tecnologico do Brasil (CNPQ), Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).


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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  1. 1.Optics Laboratory, Institute of Physics Gleb WataghinUniversity of Campinas, UNICAMPCampinasBrazil

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