Biodegradable submicrometric sieves in PLLA fabricated by soft lithography
Sieves are membranes with a regular array of uniform pores that present low flow resistance. Because of such characteristics they are promising devices for filtration, separation of particles by size and drug delivery control systems. In this paper, we propose and demonstrated the use of a soft lithography process for fabrication of biodegradable sieves in PLLA (poly-l-lactide) with pores in the scale of hundred of nanometers. The fabrication process is suitable for mass production and submicrometric pore diameters can be fabricated with homogeneity of about 15%. The PLLA self sustained sieve can be integrated to PLLA capsules, compounding a drug delivery systems or implants.
KeywordsPDMS PLLA PDMS Mold PDMS Film Interference Lithography
This work was supported by the Conselho Nacional de Desenvolvimento Cientifico e Tecnologico do Brasil (CNPQ), Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).
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