Study on design of micro-stirrer for thrombus dissolution
- 98 Downloads
The cerebral thrombus or blood clot might cause cerebral stroke and even decease if the clot could not be dissolved within several hours after it was formed. This paper presents the fundamental study on design of a micro stirrer for high effective dissolution. Based on the experimental results, the micro stirrer was analyzed by FEM with the fluid-structure interaction (FSI) analysis. The stirring effect was evaluated by the movement of the stirrer and the flow around the stirrer, and the performance index associated with the dissolution performance was presented. Using the performance index, several types of stirrers were evaluated. The obtained results demonstrated that the dissolution performance of the stirrer was influenced by the shape and the volume of the PZT actuator.
KeywordsPerformance Index Input Voltage Testing Liquid Cerebral Stroke Dissolution Performance
- Alexandrov VA, Demchuk MA, Felberg AR, Christoh I, Barber AP, Burgin W, Malkoff M, Wojner WA, Grotta CJ (2000) High rate of complete recanalization and dramatic tPA infusion when continuously monitored with 2-Mhz transcranial doppler monitoring. Stroke 31:610–614Google Scholar
- Jiang ZW, Morita M, Watanabe T, Kato S, Suzuki M (2003) Study on in-vivo measuring method of solubility for cerebral thrombus dissolution. In: Proceedings of the ICMIT, pp 356–361Google Scholar
- Tachibana K, Tachibana S (1997) Prototype therapeutic ultrasound emitting catheter for accelerating thrombolysis. J Ultrasound Med 16:529–535Google Scholar
- The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group (1995) Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 333:1581–1587Google Scholar