Journal of Anesthesia

, Volume 31, Issue 6, pp 878–884 | Cite as

Hydroxyethyl starch 130/0.4 versus crystalloid co-loading during general anesthesia induction: a randomized controlled trial

  • Takashi Juri
  • Koichi SuehiroEmail author
  • Shigemune Kuwata
  • Sayaka Tsujimoto
  • Akira Mukai
  • Katsuaki Tanaka
  • Tokuhiro Yamada
  • Takashi Mori
  • Kiyonobu Nishikawa
Original Article



Hypotension and decreased cardiac output (CO) are common adverse effects during anesthesia induction depending on the patient’s pre-anesthetic cardiac condition. The aim of this study was to assess the ability of hydroxyethyl starch (HES) 130/0.4 to prevent hypotension and decreased CO during the induction of general anesthesia.


Ninety patients undergoing laparoscopic surgery were randomly divided into a HES group and a crystalloid group. Following the insertion of an intravenous line, fluid was administered to each patient at a rate of 25 ml/min using either crystalloid or HES 130/0.4. Five minutes after the initiation of fluid loading, anesthesia was induced using propofol (1.5 mg/kg), rocuronium (0.9 mg/kg), and remifentanil (0.3 mcg/kg/min). Tracheal intubation was performed 5 min after the induction of anesthesia. Following tracheal intubation, general anesthesia was maintained using remifentanil and sevoflurane. Non-invasive blood pressure (BP) level was measured at 1-min intervals and CO was measured continuously using electrical cardiometry from the start of fluid loading until 5 min after tracheal intubation.


The number of patients with hypotension (systolic BP < 90 mmHg or 80% of baseline) was significantly lower in the HES group (p < 0.001) than in the crystalloid group. Patients in the HES group showed smaller CO decreases than did patients in the crystalloid group (p < 0.001). The Kaplan–Meier method showed a lower incidence and significantly slower onset of hypotension in the HES group (p = 0.009). Multivariate logistic regression models indicated that the use of HES is an independent factor for the prevention of both hypotension and decreased CO (below 85% of baseline; p < 0.005 for both).


Co-loading using HES 130/0.4 prevented hypotension and decreased CO during general anesthesia induction.


Cardiac output Hypotension Hydroxyethyl starch 130/0.4 


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Copyright information

© Japanese Society of Anesthesiologists 2017

Authors and Affiliations

  1. 1.Department of AnesthesiologyOsaka City University Graduate School of MedicineAbenokuJapan

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