Journal of Anesthesia

, Volume 31, Issue 6, pp 907–910 | Cite as

Epidural patch with autologous platelet rich plasma: a novel approach

  • Berrin GunaydinEmail author
  • Muberra Acar
  • Gokcen Emmez
  • Didem Akcali
  • Nil Tokgoz
Clinical Report


We aimed to perform an epidural patch using platelet rich plasma (PRP), which has the potential to regenerate and heal tissues via degranulation of platelets, in a 34-year-old parturient suffering from persistent post-dural puncture headache (PDPH) after failed epidural blood patch (EBP). After her admission to our unit, we reconfirmed the clinical and radiologic diagnosis of PDPH. Cranial MRI with contrast showed diffuse pachymeningeal thickening and contrast enhancement with enlarged pituitary consistent with intracranial hypotension. Clinical and radiological improvements were observed 1 week after the epidural patch using autologous PRP. Therefore, we recommend using autologous PRP for epidural patching in patients with incomplete recovery after standard EBP as a novel successful approach.


Epidural blood patch Platelet rich plasma Post-dural puncture headache 


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Copyright information

© Japanese Society of Anesthesiologists 2017

Authors and Affiliations

  • Berrin Gunaydin
    • 1
    Email author
  • Muberra Acar
    • 1
    • 4
  • Gokcen Emmez
    • 1
  • Didem Akcali
    • 2
  • Nil Tokgoz
    • 3
  1. 1.Department of AnesthesiologyGazi University School of MedicineBesevler-AnkaraTurkey
  2. 2.Pain ClinicGazi University School of MedicineAnkaraTurkey
  3. 3.Department of RadiologyGazi University School of MedicineAnkaraTurkey
  4. 4.Department of AnesthesiologySakarya University School of MedicineAdapazariTurkey

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