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Journal of Anesthesia

, Volume 31, Issue 5, pp 744–750 | Cite as

Electroencephalographic effect of age-adjusted 1 MAC desflurane and sevoflurane in young, middle-aged, and elderly patients

  • Shinya Kanazawa
  • Yutaka OdaEmail author
  • Chika Maeda
  • Ryu Okutani
Original Article

Abstract

Purpose

We examined the hypothesis that 1 minimum alveolar concentration (MAC) of desflurane and sevoflurane provides different depth of anesthesia.

Methods

One hundred and twenty young (20–30 years), middle-aged (31–65 years), and elderly (66–80 years) patients were randomly allocated to receive either desflurane or sevoflurane (n = 20, each group). General anesthesia was induced with propofol 2 mg/kg bolus and remifentanil 0.25 µg/kg/min, which was stopped after tracheal intubation. Maintenance of anesthesia was started with an end-tidal concentration of desflurane or sevoflurane at age-adjusted 1 MAC and maintained for 10 min, followed by 1-min assessment of bispectral index (BIS), 95% spectral edge frequency (SEF95), and amplitude of the electroencephalogram taken at 10-s intervals.

Results

BIS and SEF95 in patients receiving 1 MAC desflurane were significantly lower than those receiving 1 MAC sevoflurane including all age groups [35 (29, 39) vs. 41 (38, 49); 12.53 (10.99, 13.95) Hz vs. 14.42 (12.99, 17.17) Hz median (25, 75 percentile), respectively, P < 0.001 for both]. Both BIS and SEF95 in young patients were lower than in middle-aged and elderly patients receiving either desflurane or sevoflurane (P < 0.001 for both). There were no differences in amplitude between patients receiving desflurane and sevoflurane.

Conclusions

BIS as well as SEF95 were lower in patients receiving 1 MAC desflurane than those receiving 1 MAC sevoflurane, suggesting that desflurane provides higher depth of anesthesia than sevoflurane at 1 MAC.

Keywords

Desflurane Sevoflurane Electroencephalogram Bispectral index Spectral edge frequency 

Notes

Acknowledgements

This study was covered by departmental funding only.

Compliance with ethical standards

Conflict of interest

The authors have no conflicts of interest.

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Copyright information

© Japanese Society of Anesthesiologists 2017

Authors and Affiliations

  1. 1.Department of AnesthesiologyOsaka City General HospitalOsakaJapan

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