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Electroencephalographic effect of age-adjusted 1 MAC desflurane and sevoflurane in young, middle-aged, and elderly patients

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A Letter to the Editor to this article was published on 16 August 2019

A Letter to the Editor to this article was published on 14 August 2019

Abstract

Purpose

We examined the hypothesis that 1 minimum alveolar concentration (MAC) of desflurane and sevoflurane provides different depth of anesthesia.

Methods

One hundred and twenty young (20–30 years), middle-aged (31–65 years), and elderly (66–80 years) patients were randomly allocated to receive either desflurane or sevoflurane (n = 20, each group). General anesthesia was induced with propofol 2 mg/kg bolus and remifentanil 0.25 µg/kg/min, which was stopped after tracheal intubation. Maintenance of anesthesia was started with an end-tidal concentration of desflurane or sevoflurane at age-adjusted 1 MAC and maintained for 10 min, followed by 1-min assessment of bispectral index (BIS), 95% spectral edge frequency (SEF95), and amplitude of the electroencephalogram taken at 10-s intervals.

Results

BIS and SEF95 in patients receiving 1 MAC desflurane were significantly lower than those receiving 1 MAC sevoflurane including all age groups [35 (29, 39) vs. 41 (38, 49); 12.53 (10.99, 13.95) Hz vs. 14.42 (12.99, 17.17) Hz median (25, 75 percentile), respectively, P < 0.001 for both]. Both BIS and SEF95 in young patients were lower than in middle-aged and elderly patients receiving either desflurane or sevoflurane (P < 0.001 for both). There were no differences in amplitude between patients receiving desflurane and sevoflurane.

Conclusions

BIS as well as SEF95 were lower in patients receiving 1 MAC desflurane than those receiving 1 MAC sevoflurane, suggesting that desflurane provides higher depth of anesthesia than sevoflurane at 1 MAC.

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Notes

  1. Address: 5-15-21 Nakano-cho, Miyakojima-ku, Osaka 534-0027, Japan.

  2. https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000024542.

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Acknowledgements

This study was covered by departmental funding only.

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Authors and Affiliations

  1. Department of Anesthesiology, Osaka City General Hospital, 2-13-22 Miyakojima Hondori, Miyakojima-ku, Osaka, 534-0021, Japan

    Shinya Kanazawa, Yutaka Oda, Chika Maeda & Ryu Okutani

Authors
  1. Shinya Kanazawa
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  2. Yutaka Oda
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  3. Chika Maeda
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  4. Ryu Okutani
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Corresponding author

Correspondence to Yutaka Oda.

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Kanazawa, S., Oda, Y., Maeda, C. et al. Electroencephalographic effect of age-adjusted 1 MAC desflurane and sevoflurane in young, middle-aged, and elderly patients. J Anesth 31, 744–750 (2017). https://doi.org/10.1007/s00540-017-2391-6

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  • DOI: https://doi.org/10.1007/s00540-017-2391-6

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