Journal of Anesthesia

, Volume 31, Issue 5, pp 795–795 | Cite as

Was isoflurane the only cause of IL-1β upregulation?

  • Satoshi Ideno
  • Hiroyuki Seki
  • Hiroshi Morisaki
Letter to the Editor


Catheter General Anesthesia Proinflammatory Cytokine Isoflurane Laryngeal Mask Airway 
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To the Editor:

In the article by Whitaker et al. [1], serum interleukin-1β (IL-1β) levels significantly increased after general anesthesia in children undergoing magnetic resonance imaging. The authors concluded that brief exposure to isoflurane without surgical stress induced a systemic inflammatory response. However, the results should be interpreted carefully because this study did not include a control group.

The authors should consider the possibility that other stimuli such as intravenous catheter placement or laryngeal mask airway insertion may influence the production of inflammatory cytokines. A previous study demonstrated that a sterile needle insertion with a minor tissue injury increased the production of local proinflammatory cytokines, including IL-1β [2]. The types of airway devices used during anesthesia are known to influence systemic stress responses such as the production of proinflammatory cytokines, stress hormones, or markers for oxidative stress [3]. Even a minor stimulus should not be ignored, because the production of proinflammatory cytokines increases markedly upon its activation.

Further study is needed to confirm the causal relationship between systemic inflammatory response and general anesthesia without surgical stress.


  1. 1.
    Whitaker EE, Christofi FL, Quinn KM, Wiemann BZ, Xia JC, Tobias JD, Bissonnette B. Selective induction of IL-1β after a brief isoflurane anesthetic in children undergoing MRI examination. J Anesth. 2017 (Epub ahead of print).Google Scholar
  2. 2.
    Sjögren F, Anderson C. Sterile trauma to normal human dermis invariably induces IL1beta, IL6 and IL8 in an innate response to “danger”. Acta Derm Venereol. 2009;89:459–65.CrossRefPubMedGoogle Scholar
  3. 3.
    Tang C, Chai X, Kang F, Huang X, Hou T, Tang F, Li J. I-gel laryngeal mask airway combined with tracheal intubation attenuate systemic stress response in patients undergoing posterior fossa surgery. Mediat Inflamm. 2015;2015:965925.Google Scholar

Copyright information

© Japanese Society of Anesthesiologists 2017

Authors and Affiliations

  • Satoshi Ideno
    • 1
  • Hiroyuki Seki
    • 1
  • Hiroshi Morisaki
    • 1
  1. 1.Department of Anesthesiology, School of MedicineKeio UniversityTokyoJapan

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