Journal of Anesthesia

, Volume 31, Issue 3, pp 325–329 | Cite as

Low-dose carperitide (α-human A-type natriuretic peptide) alleviates hemoglobin concentration decrease during prolonged oral surgery: a randomized controlled study

  • Masanori TsukamotoEmail author
  • Sayuri Koyama
  • Kanako Esaki
  • Takashi Hitosugi
  • Takeshi Yokoyama
Original Article



Surgical injury stimulates the renin–angiotensin–aldosterone system (RAAS) and causes antidiuresis, leading to postoperative oliguria. Carperitide (α-human A-type natriuretic peptide) is a cardiac peptide hormone secreted from the atrium. This peptide hormone enhances diuresis by suppressing the RAAS. In our experience, carperitide alleviates decreased hemoglobin (Hb) concentration during elective surgery. In the current study, we investigated the relationship between low-dose carperitide (0.01 µg/kg/min) and Hb concentration during oral surgery.


Patients (ASA-PS: I–II, 40–80 years old) undergoing oral maxillofacial surgery (duration of operation >8 h) were enrolled in this study. Patients were divided into two groups: the carperitide group received carperitide at 0.01 µg/kg/min and the control group received normal saline. Body fluid water [including total body water (TBW), extracellular water (ECW), and intracellular water (ICW)], urine volume, and chemical parameters such as Hb concentration, PaO2, and serum electrolytes were evaluated every 2 h.


In the carperitide group (n = 15), Hb decreased from 12.6 ± 1.1 to 10.8 ± 1.5 g/dl, while it decreased from 12.6 ± 1.4 to 9.5 ± 1.3 g/dl in the control group (n = 15) (p < 0.05). Urine volume (2557.3 ± 983.5 mL) in the carperitide group was significantly more than it was in the control group (1108.8 ± 586.4 mL; p < 0.001). There were no significant differences in clinical characteristics, body fluid water, PaO2, and serum electrolytes between the two groups. In addition, there were no perioperative clinical respiratory and hemodynamic complications in the groups.


The Hb concentration in the group administered low-dose carperitide at 0.01 µg/kg/min remained higher than that in the control group during surgery. Administration of low-dose carperitide may therefore reduce the risk of blood transfusion during surgery.


α-Human A-type natriuretic peptide Hemoglobin concentration Prolonged oral surgery 


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Copyright information

© Japanese Society of Anesthesiologists 2017

Authors and Affiliations

  • Masanori Tsukamoto
    • 1
    Email author
  • Sayuri Koyama
    • 2
  • Kanako Esaki
    • 1
  • Takashi Hitosugi
    • 2
  • Takeshi Yokoyama
    • 2
  1. 1.Department of Dental AnesthesiologyKyushu University HospitalFukuokaJapan
  2. 2.Department of Dental Anesthesiology, Faculty of Dental ScienceKyushu UniversityFukuokaJapan

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