Journal of Anesthesia

, Volume 29, Issue 3, pp 421–425 | Cite as

Concomitant administration of nitrous oxide and remifentanil reduces oral tissue blood flow without decreasing blood pressure during sevoflurane anesthesia in rabbits

  • Masataka Kasahara
  • Tatsuya Ichinohe
  • Sota Okamoto
  • Reina Okada
  • Hiroaki Kanbe
  • Nobuyuki Matsuura
Original Article
  • 190 Downloads

Abstract

Purpose

To determine whether continuous administration of nitrous oxide and remifentanil—either alone or together—alters blood flow in oral tissues during sevoflurane anesthesia.

Methods

Eight male tracheotomized Japanese white rabbits were anesthetized with sevoflurane under mechanical ventilation. Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), common carotid arterial blood flow (CCBF), tongue mucosal blood flow (TMBF), mandibular bone marrow blood flow (BBF), masseter muscle blood flow (MBF), upper alveolar tissue blood flow (UBF), and lower alveolar tissue blood flow (LBF) were recorded in the absence of all test agents and after administration of the test agents (50 % nitrous oxide, 0.4 μg/kg/min remifentanil, and their combination) for 20 min.

Results

Nitrous oxide increased SBP, DBP, MAP, CCBF, BBF, MBF, UBF, and LBF relative to baseline values but did not affect HR or TMBF. Remifentanil decreased all hemodynamic variables except DBP. Combined administration of nitrous oxide and remifentanil recovered SBP, DBP, MAP, and CCBF to baseline levels, but HR and oral tissue blood flow remained lower than control values.

Conclusions

Our findings suggest that concomitant administration of nitrous oxide and remifentanil reduces blood flow in oral tissues without decreasing blood pressure during sevoflurane anesthesia in rabbits.

Keywords

Oral tissue blood flow Nitrous oxide Remifentanil Sevoflurane 

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Copyright information

© Japanese Society of Anesthesiologists 2014

Authors and Affiliations

  • Masataka Kasahara
    • 1
  • Tatsuya Ichinohe
    • 2
  • Sota Okamoto
    • 2
  • Reina Okada
    • 2
  • Hiroaki Kanbe
    • 2
  • Nobuyuki Matsuura
    • 2
  1. 1.Department of PharmacologyTokyo Dental CollegeTokyoJapan
  2. 2.Department of Dental AnesthesiologyTokyo Dental CollegeTokyoJapan

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