Journal of Anesthesia

, Volume 28, Issue 2, pp 257–266 | Cite as

Pharmacological and nonpharmacological prevention of fentanyl-induced cough: a meta-analysis

  • Ji Eun Kim
  • Sang Kee Min
  • Yun Jeong Chae
  • Yeon Ju Lee
  • Bong Ki Moon
  • Jong Yeop Kim
Review Article


Fentanyl-induced cough (FIC) is often observed after intravenous bolus administration of fentanyl during anesthesia induction. This meta-analysis assessed the efficacy of pharmacological and nonpharmacological interventions to reduce the incidence of FIC. We searched for randomized controlled trials comparing pharmacological or nonpharmacological interventions with controls to prevent FIC; we included 28 studies retrieved from PubMed, Embase, and Cochrane Library. Overall incidence of FIC was approximately 31 %. Lidocaine [odds ratio (OR)  = 0.29, 95 % confidence interval (CI) 0.21–0.39], N-methyl-D-aspartate (NMDA) receptor antagonists (OR 0.09, 95 % CI 0.02–0.42), propofol (OR 0.07, 95 % CI 0.01–0.36), α2 agonists (OR 0.32, 95 % CI 0.21–0.48), β2 agonists (OR 0.10, 95 % CI 0.03–0.30), fentanyl priming (OR 0.33, 95 % CI 0.19–0.56), and slow injection of fentanyl (OR 0.25, 95 % CI 0.11–0.58)] were effective in decreasing the incidence of FIC, whereas atropine (OR 1.10, 95 % CI 0.58–2.11) and benzodiazepines (OR 2.04, 95 % CI 1.33–3.13) were not effective. This meta-analysis found that lidocaine, NMDA receptor antagonists, propofol, α2 agonists, β2 agonists, and priming dose of fentanyl were effective in preventing FIC, but atropine and benzodiazepines were not. Slow injection of fentanyl was effective in preventing FIC, but results depend on the speed of administration.


Anesthesia Fentanyl-induced cough Meta-analysis Prevention 


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Copyright information

© Japanese Society of Anesthesiologists 2013

Authors and Affiliations

  • Ji Eun Kim
    • 1
  • Sang Kee Min
    • 2
  • Yun Jeong Chae
    • 2
  • Yeon Ju Lee
    • 2
  • Bong Ki Moon
    • 2
  • Jong Yeop Kim
    • 2
  1. 1.Department of Anesthesiology and Pain MedicineYonsei University College of MedicineSeoulKorea
  2. 2.Department of Anesthesiology and Pain MedicineAjou University School of MedicineSuwonKorea

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