Journal of Anesthesia

, Volume 27, Issue 6, pp 942–944 | Cite as

Early postoperative cognitive dysfunction is associated with higher cortisol levels in aged patients following hip fracture surgery

  • Mu-Huo Ji
  • Jin-Chun Shen
  • Rong Gao
  • Xiao-Yu Liu
  • Hong-Mei Yuan
  • Lin Dong
  • Jing Wu
  • Shan-Wu Feng
  • Wei-Yan Li
  • Jian-Jun Yang
Short Communication

Abstract

This study aimed to evaluate the relationship between plasma cortisol levels and the occurrence of postoperative cognitive dysfunction (POCD) in aged patients following hip fracture surgery. A total of 175 patients, aged 65 years or older, who were scheduled for hip fracture surgery with spinal anesthesia were enrolled. Perioperative plasma levels of cortisol and neurocognitive tests were determined at 1 day preoperatively and 7 days postoperatively. Seventy-seven patients completed both blood sample collections and neurocognitive tests. POCD occurred in 29.9 % of patients at 7 days postoperatively. POCD patients presented significantly higher cortisol levels compared with non-POCD patients (P < 0.05). Furthermore, plasma cortisol levels were negatively correlated with mini-mental state examination (MMSE) scores at 7 days postoperatively (P < 0.0001). A specificity of 93 % and a sensitivity of 35 % were identified for the plasma cortisol measurement to discriminate POCD patients from non-POCD patients. The results suggest higher plasma cortisol levels are associated with POCD in aged patients following hip fracture surgery with spinal anesthesia.

Keywords

Postoperative cognitive dysfunction Cortisol Plasma 

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Copyright information

© Japanese Society of Anesthesiologists 2013

Authors and Affiliations

  • Mu-Huo Ji
    • 1
  • Jin-Chun Shen
    • 1
  • Rong Gao
    • 1
  • Xiao-Yu Liu
    • 1
  • Hong-Mei Yuan
    • 2
  • Lin Dong
    • 1
  • Jing Wu
    • 1
  • Shan-Wu Feng
    • 2
  • Wei-Yan Li
    • 1
  • Jian-Jun Yang
    • 1
  1. 1.Department of Anesthesiology, Jinling Hospital, School of MedicineNanjing UniversityNanjingChina
  2. 2.Department of Anesthesiology, Nanjing Maternity and Child Health Care HospitalNanjing Medical UniversityNanjingChina

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