Journal of Anesthesia

, Volume 27, Issue 4, pp 569–574 | Cite as

The effects of secondhand smoke on postoperative pain and fentanyl consumption

  • Mustafa Said Aydogan
  • Erdogan Ozturk
  • Mehmet Ali Erdogan
  • Aytac Yucel
  • Mahmut Durmus
  • Mehmet Ozcan Ersoy
  • Cemil Colak
Original Article



Although the need for increased postoperative analgesia in smokers has been described, the effect of secondhand smoke on postoperative analgesia requirements has not been studied. We examined the effects of secondhand smoke on fentanyl consumption and postoperative pain.


In this study, 101 patients (American Society of Anesthesiology physical status I and II) who underwent abdominal hysterectomy were divided into 3 groups according to history of exposure to cigarette smoke as per medical records which was retrospectively confirmed by measurement of serum cotinine: smokers (n = 28), nonsmokers (n = 31), and secondhand smokers (n = 32). All patients received propofol–remifentanil total intravenous anesthesia and used fentanyl patient controlled analgesia for postoperative pain. The fentanyl consumption visual analogue scale-pain intensity (VAS-PI) score and side effects were recorded in the postanesthesia care unit (PACU) and at 2, 4, 6, and 24 h after surgery.


Fentanyl consumption at all the evaluation time points was significantly higher in secondhand smokers than in nonsmokers (P < 0.05). However, fentanyl consumption in secondhand smokers was lower than that in smokers in the PACU and at 24 h (P < 0.05). VAS-PI scores during movement and at rest in the PACU and at 4, 6, and 24 h after surgery were higher in secondhand smokers than in nonsmokers (P < 0.05). There were no statistically significant differences between the groups with regard to side effects such as nausea, vomiting, and dizziness (P > 0.05).


Secondhand smoking was associated with increased postoperative fentanyl consumption, and increased VAS-PI scores. These findings may be beneficial for managing postoperative pain in secondhand smokers.


Secondhand smoke Fentanyl consumption Pain Postoperative 


Conflict of interest

The authors received no financial support. The authors have indicated that they have no conflicts of interest regarding the content of this article.


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Copyright information

© Japanese Society of Anesthesiologists 2013

Authors and Affiliations

  • Mustafa Said Aydogan
    • 1
  • Erdogan Ozturk
    • 2
  • Mehmet Ali Erdogan
    • 1
  • Aytac Yucel
    • 1
  • Mahmut Durmus
    • 1
  • Mehmet Ozcan Ersoy
    • 1
  • Cemil Colak
    • 3
  1. 1.Department of Anesthesiology and ReanimationInonu University, Faculty of MedicineMalatyaTurkey
  2. 2.Department of Anesthesiology and ReanimationBezm-i Alem University, Faculty of MedicineIstanbulTurkey
  3. 3.Department of Biostatistics and Medical InformaticsInonu University, Faculty of MedicineMalatyaTurkey

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