Journal of Anesthesia

, Volume 27, Issue 2, pp 236–242 | Cite as

Changes in plasma and cerebrospinal fluid biomarkers in aged patients with early postoperative cognitive dysfunction following total hip-replacement surgery

  • Mu-Huo Ji
  • Hong-Mei Yuan
  • Guang-Fen Zhang
  • Xiao-Min Li
  • Lin Dong
  • Wei-Yan Li
  • Zhi-Qiang Zhou
  • Jian-Jun Yang
Original Article



We hypothesized that different patterns of biomarkers of brain injury and inflammation exist in aged patients with postoperative cognitive dysfunction (POCD) after total hip-replacement with spinal anesthesia.


Eighty-three patients older than 65 years undergoing elective total hip-replacement surgery were enrolled in this prospective observational study. The CSF levels of Tau, phosphorylated-tau (pTau), amyloidβ1–42 (Aβ1–42), Tau/Aβ1–42, pTau/Aβ1–42, BDNF, IL-6, and IL-1β were measured preoperatively. Perioperative plasma levels of IL-1β, IL-6, brain-derived neurotrophic factor (BDNF), C-reactive protein (CRP), and malonaldehyde (MDA) as well as neurocognitive tests were determined preoperatively and seven days postoperatively.


Sixty-one patients completed both the CSF and blood samples collection and the neurocognitive tests. POCD occurred in 24.6 % of patients at seven days after surgery. Patients with POCD had significantly higher IL-1β, Tau/Aβ1–42, pTau/Aβ1–42, and a lower level of Aβ1–42 in CSF when compared with the Non-POCD group (P < 0.05). Furthermore, POCD patients displayed significantly higher plasma levels of MDA when compared with Non-POCD patients at seven days after surgery (P < 0.05). There was no difference in preoperative CSF levels of Tau, IL-6, and pTau as well as plasma levels of IL-1β, IL-6, BDNF and CRP between POCD and Non-POCD groups (P > 0.05).


The POCD patients were associated with higher postoperative plasma levels of MDA, and higher IL-1β and lower Aβ1–42 levels in preoperative CSF that might predispose the development of POCD in aged patients following total hip-replacement surgery with spinal anesthesia.


Postoperative cognitive dysfunction Biomarker Spinal anesthesia Cerebrospinal fluid Plasma 


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Copyright information

© Japanese Society of Anesthesiologists 2012

Authors and Affiliations

  • Mu-Huo Ji
    • 1
  • Hong-Mei Yuan
    • 2
  • Guang-Fen Zhang
    • 1
  • Xiao-Min Li
    • 1
  • Lin Dong
    • 1
  • Wei-Yan Li
    • 1
  • Zhi-Qiang Zhou
    • 1
  • Jian-Jun Yang
    • 1
  1. 1.Department of AnesthesiologyJinling Hospital, School of Medicine, Nanjing UniversityNanjingChina
  2. 2.Department of AnesthesiologyNanjing Maternity and Child Health Care Hospital, Nanjing Medical UniversityNanjingChina

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