Journal of Anesthesia

, Volume 26, Issue 4, pp 601–605 | Cite as

Use of dexmedetomidine for the treatment of alcohol withdrawal syndrome in critically ill patients: a retrospective case series

  • Jonas P. DeMuro
  • David G. Botros
  • Ela Wirkowski
  • Adel F. Hanna
Clinical Report


Alcohol withdrawal syndrome (AWS) continues to be a challenge to manage in the ICU setting, and the ideal pharmacological treatment continues to evolve. Dexmedetomidine is a newer agent approved for short-term sedation in the ICU, but its use in the treatment of AWS has been limited. We report a retrospective case series of ten patients who were identified as receiving dexmedetomidine for AWS as designated by electronic pharmacy records. All subjects were male, with a mean age of 53.6 years, and a mean ICU length of stay of 9.3 days. They were all diagnosed with AWS by DSM-IV criteria. All the study patients received dexmedetomidine during their hospital course as a treatment for AWS. Studied variables included demographic data, dose and duration of dexmedetomidine, other pharmaceutical agents, and hemodynamics. Dexmedetomidine was safe to use in all patients, although mechanical ventilation was still required in three patients. With dexmedetomidine, the autonomic hyperactivity was blunted, with a mean 12.8 % reduction in rate pressure product observed. Consideration should be given to the combined use of dexmedetomidine with benzodiazepines in the treatment of AWS.


Dexmedetomidine Alcohol withdrawal syndrome Pharmacological therapy Alcohol Critical care 



The authors have no financial or ethical interests to disclose relevant to this submission. There was no financial support for this study from any source, institutional or outside.


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Copyright information

© Japanese Society of Anesthesiologists 2012

Authors and Affiliations

  • Jonas P. DeMuro
    • 1
  • David G. Botros
    • 1
  • Ela Wirkowski
    • 2
  • Adel F. Hanna
    • 1
  1. 1.Division of Trauma and Critical Care, Department of SurgeryWinthrop University HospitalMineolaUSA
  2. 2.Neurosciences Special Care Unit, Department of NeurosciencesWinthrop University HospitalMineolaUSA

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