Journal of Anesthesia

, Volume 26, Issue 4, pp 595–597

Perioperative management of a patient with thyroid hormone resistance who underwent total thyroidectomy for thyroid cancer

Clinical Report


Resistance to thyroid hormone (RTH) is a rare, predominantly inherited syndrome that involves impaired tissue responsiveness to thyroid hormones. We describe the perioperative management of a patient with RTH who underwent total thyroidectomy. Although surgery performed under general anesthesia was uneventful, after the surgery the patient developed difficult-to-treat hypocalcemia that lasted until postoperative day 4. Moreover, thyroid function even after discharge remained unstable despite replacement therapy. We suggest that the parathyroid and thyroid function of patients with RTH be followed very closely and that nociceptive stimulus of the surgery and postoperative pain be reduced as much as possible.


Resistance to thyroid hormone Thyroidectomy Thyroid cancer Hypocalcemia 

Copyright information

© Japanese Society of Anesthesiologists 2012

Authors and Affiliations

  1. 1.Department of AnesthesiologyKumamoto University HospitalKumamotoJapan
  2. 2.Department of Dental SurgeryKumamoto University HospitalKumamotoJapan
  3. 3.Department of Anesthesiology, Graduate School of Medical ScienceKumamoto UniversityKumamotoJapan

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