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Journal of Anesthesia

, Volume 26, Issue 4, pp 525–530 | Cite as

Feasibility and safety of transglottic bronchoscopy in mechanically ventilated sheep

  • Saeid Amanpour
  • Hamidreza AbtahiEmail author
  • Shahram Rabbani
  • Samad Muhammadnezhad
Original Article
  • 106 Downloads

Abstract

Purpose

Although bronchoscopy can be safely performed through endotracheal tube in most intubated critically ill patients, sometimes it could lead to complications such as hypoxia and high airway pressures. Theoretically, transglottic bronchoscopy (TGB) does not interfere with mechanical ventilation and could avoid these complications. In a two-period crossover study, we compared this technique with trans-endotracheal tube bronchoscopy (TEB) in normal anesthetized sheep.

Methods

In five sheep, we did TGB first. The bronchoscope was introduced through the nasal nares and passed into the trachea via space between endotracheal tube and vocal folds. Heart rate, V T, P peak, and O2 saturation were recorded. One week later, we did TEB. In another five sheep, we did TEB first and TGB later.

Results

P peak increased and V T and O2 saturation decreased during TEB (53.2 ± 5.7 vs. 27.6 ± 0.6, P = 0.002; 210 ± 32 vs. 285 ± 26, P = 0.002; 94.3 ± 1.3 vs. 97.5% ± 0.5, P = 0.041, respectively), but not during TGB. The only statistically significant abnormal finding during TGB was a mild tachycardia (96.7 ± 5.7 vs. 94.7 ± 5.5, P = 0.034).

Conclusion

Although TGB is time consuming and less convenient than TEB, it has minimal interference with mechanical ventilation. Expertise with this technique could be useful in patients with anticipated significant hypoxia and high airway pressures during bronchoscopy.

Keywords

Transglottic bronchoscopy Trans-endotracheal tube bronchoscopy Mechanical ventilation Sheep 

Notes

Acknowledgments

This work was supported by Tehran University of Medical Sciences (Project No. 132-4987).

Supplementary material

Online Resource 1: Video clip of transglottic bronchoscopy in sheep model (MPG 21474 kb)

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Copyright information

© Japanese Society of Anesthesiologists 2012

Authors and Affiliations

  • Saeid Amanpour
    • 1
  • Hamidreza Abtahi
    • 2
    • 3
    Email author
  • Shahram Rabbani
    • 4
  • Samad Muhammadnezhad
    • 1
  1. 1.Cancer Research Centre, Cancer InstituteTehran University of Medical SciencesTehranIslamic Republic of Iran
  2. 2.Pulmonary and Critical Care Department, Imamkhomeini Medical CentreTehran University of Medical SciencesTehranIslamic Republic of Iran
  3. 3.Advanced Thoracic Research CentreTehran University of Medical SciencesTehranIslamic Republic of Iran
  4. 4.Research Department, Tehran Heart CentreTehran University of Medical SciencesTehranIslamic Republic of Iran

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