Passiflora incarnata Linneaus as an anxiolytic before spinal anesthesia
Patients who undergo regional anesthesia experience anxiety in the preoperative period. Passiflora incarnata Linneaus is a plant that has traditionally been used as an anxiolytic and sedative. We aimed to investigate the effect of preoperative oral administration of Passiflora incarnata Linneaus on anxiety, psychomotor functions, sedation, and hemodynamics in patients undergoing spinal anesthesia.
Under local ethics committee approval, 60 patients who were aged 25–55 years and ASAI–II and who were scheduled for spinal anesthesia were enrolled in this prospective, randomized, double-blind and placebo-controlled study. Thirty minutes before spinal anesthesia, baseline hemodynamic parameters, State-Trait Anxiety Inventory (STAI) score, sedation score, and psychomotor function test results were measured, then patients were randomly assigned to two groups: oral Passiflora incarnata Linneaus extract or placebo was given to the patients. Tests were repeated just before spinal anesthesia. Hemodynamics, sedation score, sensory-motor block and side effects were assessed during the operation. Psychomotor function tests were repeated at the end of the operation and 60 min after the operation.
There was a statistically significant difference between the two groups for the increase in State Anxiety Inventory (STAI-S) score obtained just before spinal anesthesia when compared to the baseline. There was no statistically significant difference in psychomotor function from the baseline for either group. A significant difference was not found between the two groups in demographics, psychomotor function, sedation score, hemodynamics, and side effects.
Oral preoperative administration of Passiflora incarnata Linneaus suppresses the increase in anxiety before spinal anesthesia without changing psychomotor function test results, sedation level, or hemodynamics.
KeywordsAnesthesia Spinal Anxiety Passiflora incarnata
- 3.Mills S, Bone K (eds). Principles and practice of phytotherapy. Edinburgh: Churchill Livingstone; 2000. p. 232–3.Google Scholar
- 10.Miyasaka LS, Atallah AN, Soares BG. Passiflora for anxiety disorder. Cochrane Database Syst Rev. 2007;24:CD004518.Google Scholar
- 11.Ersnst E. Herbal remedies for anxiety—a systematic review of controlled clinical trials. Phytomedicine. 2006;13:205–8.Google Scholar
- 12.Spielberger CD. Manuel for the State-Trait Anxiety Inventory (Form Y). Palo Alto: Consulting Psychologists Press Inc.; 1983.Google Scholar
- 13.Goyal N, Ramakrishna B, Bhandarkar S. A comparative evaluation of the characteristics of recovery from anaesthesia with isoflurane and halothane in day-care surgery. Indian J Anaesth. 2006;50:183–6.Google Scholar
- 17.Loli F, Sato CM, Romanini CV, Viaggi Billas-Boas LD, Moraes Santos CA, de Oliveira RMW. Possible involvement of GABAA-benzodiazepine receptor in the anxiolytic-like effect induced by Passiflora actinia extracts in mice. J Ethnopharmacol. 2007;111:308–14.Google Scholar
- 19.Blumenthal M. The Complete German Commission E Monographs. Therapeutic guide to herbal medicines. Austin: American Botanical Council; 1998.Google Scholar
- 22.Fisher AA, Purcell P, Le Couteur DG. Toxicity of Passiflora incarnata L. J Toxicol Clin Toxicol. 2000;38:63–6.Google Scholar