Journal of Anesthesia

, Volume 25, Issue 4, pp 516–522

The effect of target-controlled infusion of low-dose ketamine on heat pain and temporal summation threshold

  • Joon-Ho Lee
  • Sung-Hwan Cho
  • Sang-Hyun Kim
  • Won-Soek Chae
  • Hee-Cheol Jin
  • Jeong-Seok Lee
  • Yong-Ik Kim
Original Article

Abstract

Purpose

We investigated the heat pain threshold (HPT) and temporal summation threshold (TST) before and after target-controlled infusion (TCI) of ketamine with an effect-site concentration (Ce) of 30 and 60 ng/ml.

Methods

Healthy young volunteers (n = 20) were enrolled. A thermode was applied to the volar side of each volunteer’s right forearm, and HPT and TST were measured before and after TCI of ketamine. Vital signs and psychedelic effects according to ketamine infusion were also observed before and after TCI of ketamine.

Results

Mean HPT after TCI of ketamine with a Ce of 30 and 60 ng/ml did not increase significantly. However, mean TST after TCI of ketamine with a Ce of 30 and 60 ng/ml increased significantly, in a dose-dependent fashion, compared with the value before ketamine TCI. Vital signs showed no significant difference before and after ketamine TCI. The visual analog scale score of psychedelic symptoms was higher with a Ce of 60 ng/ml than with 30 ng/ml.

Conclusions

TCI of ketamine with a Ce of 30 and 60 ng/ml increased TST but not HPT.

Keywords

Heat pain threshold Low-dose ketamine Quantitative sensory testing Temporal summation 

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Copyright information

© Japanese Society of Anesthesiologists 2011

Authors and Affiliations

  • Joon-Ho Lee
    • 1
  • Sung-Hwan Cho
    • 1
  • Sang-Hyun Kim
    • 1
  • Won-Soek Chae
    • 1
  • Hee-Cheol Jin
    • 1
  • Jeong-Seok Lee
    • 1
  • Yong-Ik Kim
    • 1
  1. 1.Department of Anesthesiology and Pain MedicineUniversity of Soonchunhyang, Bucheon HospitalBucheon-SiKorea

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