Journal of Anesthesia

, Volume 24, Issue 3, pp 426–431

Effect of intraoperative acetated Ringer’s solution with 1% glucose on glucose and protein metabolism

  • Kazumasa Yamasaki
  • Yoshimi Inagaki
  • Shinsuke Mochida
  • Kazumi Funaki
  • Shunsaku Takahashi
  • Seiji Sakamoto
Original Article



To investigate the effects of the intraoperative administration of Ringer’s solution with 1% glucose on the metabolism of glucose, lipid and muscle protein during surgery.


Thirty-one adult patients, American Society of Anesthesiologists physical status I or II, undergoing elective otorhinolaryngeal, head and neck surgeries were randomly assigned to one of two patient groups: those receiving acetated Ringer’s solution with 1% glucose (Group G) or those receiving acetated Ringer’s solution without glucose (Group R) throughout the surgical procedure. Plasma glucose was measured at anesthetic induction (T0), artery 1 h (T1), 2 h (T2), 3 h after anesthetic induction (T3) and at the end of surgery (T4). Plasma ketone bodies, insulin and 3-methylhistidine were measured at T0 and T4.


The intravenous infusion for patients in Group G and R was 6.1 ± 0.8 and 6.3 ± 1.7 ml/kg/h, respectively, with Group G patients receiving a dose of 4.1 g/h glucose. Plasma glucose levels were significantly higher in Group G than in Group R patients at T1, T2, T3 and T4; however, plasma glucose remained <150 mg/dl in both groups. The plasma concentration of ketone bodies was significantly higher (P < 0.05) in Group R than in Group G patients at T4. Changes in plasma 3-methylhistidine concentration was significantly lower in Group G than in Group R patients. These results indicate that acetated Ringer’s solution with 1% glucose decreased protein catabolism without hyperglycemia among the Group G patients.


The infusion of a small dose of glucose (1%) during minor otorhinolaryngeal, head and neck surgeries may suppress protein catabolism without hyperglycemia and hypoglycemia.


Glucose Intraoperative nutrition 3-Methylhistidine Protein metabolism 


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Copyright information

© Japanese Society of Anesthesiologists 2010

Authors and Affiliations

  • Kazumasa Yamasaki
    • 1
  • Yoshimi Inagaki
    • 1
  • Shinsuke Mochida
    • 1
  • Kazumi Funaki
    • 1
  • Shunsaku Takahashi
    • 1
  • Seiji Sakamoto
    • 1
  1. 1.Department of Anesthesiology and Critical Care MedicineTottori University Faculty of MedicineYonagoJapan

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