Journal of Anesthesia

, Volume 22, Issue 1, pp 64–69 | Cite as

Clinical role and efficacy of landiolol in the intensive care unit

  • Yuko Yoshida
  • Katsuyuki Terajima
  • Chiyo Sato
  • Shinji Akada
  • Yasuo Miyagi
  • Takashi Hongo
  • Shinhiro Takeda
  • Keiji Tanaka
  • Atsuhiro Sakamoto
Clinical Reports


Beta-adrenergic receptor blockers have proved to be effective for the management of various cardiovascular diseases and the prevention of perioperative cardiac events and cerebrovascular accidents. Landiolol is a short-acting beta-blocker, with high beta 1-selectivity and a short duration of action. We thought landiolol was valuable and suitable for intensive care unit (ICU) patients, and conducted a retrospective study. The records of 80 patients (58 post-surgical patients; group S and 22 internal medicine patients; group IM) were reviewed. Thirty-seven (64%) of the group S patients were post-coronary artery bypass graft surgery, and the IM group consisted mostly of patients with acute myocardial infarction. The most common indication for landiolol in group S was the prevention of myocardial ischemia (50%), and in group IM, it was atrial fibrillation (45%). The median infusion rate of landiolol was 5 μg·kg−1·min−1 and the median infusion time was 2 days. Twenty-six patients were continued on oral beta-adrenergic receptor blockers. Landiolol reduced heart rate significantly without reducing blood pressure, and stabilized hemodynamics. We confirmed that landiolol is valuable as a bridge to starting oral beta-adrenergic receptor blockers and as an anti-arrhythmic agent, and that it is suitable for ICU patients due to its high beta 1-selectivity and rapid onset and offset of action.

Key words

Landiolol Beta-adrenergic receptor blocker Intensive care unit Atrial fibrillation Myocardial ischemia 


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Copyright information

© Japanese Society of Anesthesiologists 2008

Authors and Affiliations

  • Yuko Yoshida
    • 1
  • Katsuyuki Terajima
    • 1
  • Chiyo Sato
    • 1
  • Shinji Akada
    • 1
    • 2
  • Yasuo Miyagi
    • 2
  • Takashi Hongo
    • 1
    • 2
  • Shinhiro Takeda
    • 1
    • 2
  • Keiji Tanaka
    • 2
  • Atsuhiro Sakamoto
    • 1
  1. 1.Department of AnesthesiologyNippon Medical SchoolTokyoJapan
  2. 2.Division of Intensive and Coronary Care UnitNippon Medical School HospitalTokyoJapan

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