Advertisement

Journal of Gastroenterology

, Volume 37, Issue 5, pp 376–380 | Cite as

Duodenal cancer in a patient with Peutz-Jeghers syndrome: molecular analysis

  • Toshio Nakamura
  • Shohachi Suzuki
  • Yoshihiro Yokoi
  • Hidefumi Kashiwabara
  • Keiji Maruyama
  • Satoshi Baba
  • Hidewaki Nakagawa
  • Satoshi Nakamura
Case report

APC

and K-ras genes, which is a critical step for the adenoma-carcinoma sequence in colon cancer. Importantly, a germline mutation of the STK11 gene was detected at codon 281 delC in exon 6. Moreover, the tumor showed loss of heterozygosity of the 19p marker near STK11 and somatic mutation of the p53 gene. These findings suggest that STK11 is a tumor suppressor gene regulating the development of hamartomas, and that somatic mutation of p53 subsequently promotes gastrointestinal cancer at a later stage in PJS.

Key words: Peutz-Jeghers syndrome duodenal cancer STK11 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag Tokyo 2002

Authors and Affiliations

  • Toshio Nakamura
    • 1
  • Shohachi Suzuki
    • 1
  • Yoshihiro Yokoi
    • 1
  • Hidefumi Kashiwabara
    • 1
  • Keiji Maruyama
    • 1
  • Satoshi Baba
    • 2
  • Hidewaki Nakagawa
    • 3
  • Satoshi Nakamura
    • 1
  1. 1.Second Department of Surgery, Hamamatsu University School of Medicine, 3600 Handa-cho, Hamamatsu 431-3192, JapanJP
  2. 2.Second Department of Pathology, Hamamatsu University School of Medicine, Hamamatsu, JapanJP
  3. 3.Second Department of Surgery, Osaka Medical School, Osaka, JapanJP

Personalised recommendations