Journal of Gastroenterology

, Volume 34, Issue 6, pp 706–712

Epstein-Barr virus infection resembling autoimmune hepatitis with lactate dehydrogenase and alkaline phosphatase anomaly

  • Kyoko Kojima
  • Ryozo Nagayama
  • Sachio Hirama
  • Tomomi Maeda
  • Hajime Takikawa
  • Kazuhiko Miyake
  • Masami Yamanaka
  • Junji Shiga
Case report

DOI: 10.1007/s005350050324

Cite this article as:
Kojima, K., Nagayama, R., Hirama, S. et al. J Gastroenterol (1999) 34: 706. doi:10.1007/s005350050324

Abstract:

A 73-year-old man had fever, lymphadenopathy, granulocytopenia, thrombocytopenia, ascites, pleural effusion, liver injury, and an allergic-like skin rash. Autoantibodies, such as anti-nuclear antibody, were shown, and there were lactate dehydrogenase and alkaline phosphatase anomalies and platelet-associated IgG. His liver injury resembled that in autoimmune hepatitis. He was diagnosed with Epstein-Barr virus (EBV) infection associated with autoimmunization because of his clinical course, fluctuation of anti EBV antibodies and positive EBV genome in circulating lymphocytes and serum. This case suggests a close relationship between EBV infection and autoimmunization or autoimmune-like hepatitis.

Key words: Epstein-Barr virus infection autoimmune hepatitis autoimmunization lactate dehydrogenase anomaly alkaline phosphatase anomaly 

Copyright information

© Springer-Verlag Tokyo 1999

Authors and Affiliations

  • Kyoko Kojima
    • 1
  • Ryozo Nagayama
    • 1
  • Sachio Hirama
    • 1
  • Tomomi Maeda
    • 1
  • Hajime Takikawa
    • 1
  • Kazuhiko Miyake
    • 1
  • Masami Yamanaka
    • 1
  • Junji Shiga
    • 2
  1. 1.Department of Medicine, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, JapanJP
  2. 2.Department of Pathology, Teikyo University School of Medicine, Tokyo, JapanJP

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