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Journal of Gastroenterology

, Volume 33, Issue 2, pp 218–222 | Cite as

Sero-epidemiologic study of hepatitis C virus infection in Fukuoka, Japan

  • Michio Sata
  • Hitoshi Nakano
  • Hiroshi Suzuki
  • Seiji Noguchi
  • Yohsuke Yamakawa
  • Eisuke Tanaka
  • Kunitaka Fukuizumi
  • Kumi Tanaka
  • Hiroshi Yoshida
  • Kyuichi Tanikawa

Abstract:

We conducted an epidemiological study of 509 residents of H town, Fukuoka, Japan, to investigate the high mortality rate from liver disease. Antibodies to hepatitis C virus (HCV) (anti-HCV) were detected in 120 residents (23.6%); HCV RNA in 91 (17.9%), and hepatitis B surface antigen (HBsAg) in 13 (2.6%). Multivariate logistic regression analyses showed that presence of anti-HCV, male gender, and history of liver disease were associated with the presence of liver dysfunction, and that age of more than 40 years and a particular district were associated with the presence of anti-HCV. HCV RNA was more frequently detected in anti-HCV-positive men than women (41, or 85.4% versus 50, or 69.4%) (P < 0.05). The incidence of liver dysfunction was significantly higher in HCV RNA-positive men than women (32, or 66.7% versus 22, or 30.6%) (P < 0.05). These findings suggest that: (1) HCV was correlated with the high mortality rate from liver diseases, (2) there were district-related differences in the incidence of HCV, and (3) the lower frequency of elimination of HCV from men may explain why they showed a high mortality from liver disease.

Key words: hepatitis C virus (HCV) HCV hyper-endemic area HCV RNA 

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Copyright information

© Springer-Verlag Tokyo 1998

Authors and Affiliations

  • Michio Sata
    • 1
  • Hitoshi Nakano
    • 2
  • Hiroshi Suzuki
    • 1
  • Seiji Noguchi
    • 1
  • Yohsuke Yamakawa
    • 1
  • Eisuke Tanaka
    • 1
  • Kunitaka Fukuizumi
    • 1
  • Kumi Tanaka
    • 1
  • Hiroshi Yoshida
    • 1
  • Kyuichi Tanikawa
    • 1
  1. 1.Second Department of Medicine, Kurume University School of Medicine, 67 Asahi-Machi, Kurume 830, JapanJP
  2. 2.Nakano Naika Syohkaki-ka, Chikugo, JapanJP

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