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Journal of Gastroenterology

, Volume 54, Issue 9, pp 784–791 | Cite as

Time trends in the incidence of esophageal adenocarcinoma, gastric adenocarcinoma, and superficial esophagogastric junction adenocarcinoma

  • Kenshi Matsuno
  • Ryu IshiharaEmail author
  • Masayasu Ohmori
  • Hiroyoshi Iwagami
  • Satoki Shichijyo
  • Akira Maekawa
  • Takashi Kanesaka
  • Sachiko Yamamoto
  • Yoji Takeuchi
  • Koji Higashino
  • Noriya Uedo
  • Takashi Matsunaga
  • Toshitaka Morishima
  • Isao Miyashiro
Original Article—Alimentary Tract
  • 497 Downloads

Abstract

Background

In Japan, the incidence of esophageal adenocarcinoma (EAC) and esophagogastric junction (EGJ) adenocarcinoma is expected to increase and that of gastric adenocarcinoma (GAC) is expected to decrease due to Westernization of the diet and the decreasing prevalence of Helicobacter pylori infection. However, few reports about these trends have included the latest data, and no reports about the time trend in the incidence of EGJ adenocarcinoma have focused on the etiologies (gastric cardia adenocarcinoma or EAC, including Barrett’s adenocarcinoma). We therefore investigated the time trends in the incidence of these cancers by including the latest data.

Methods

First, we investigated the time trends in EAC and GAC using population-based cancer registry data in Osaka Prefecture (1985–2014). We then investigated the time trend in superficial EGJ adenocarcinoma with clinicopathological features at Osaka International Cancer Institute (2006–2017).

Results

From 1985 to 2014 in Osaka Prefecture, the incidence of EAC gradually increased in both sexes, while that of GAC in men did not significantly change and that in women decreased. The ratio of the EAC/GAC incidence increased 3.5 times in men and 1.8 times in women. In the secondary time trend survey for EGJ adenocarcinoma, the numbers of patients with endoscopic Barrett’s esophagus and those without gastric mucosal atrophy increased, and the number of patients with lesions located above the EGJ line and histologically diagnosed as Barrett’s adenocarcinoma increased.

Conclusions

The incidence of EAC and superficial EGJ adenocarcinoma with characteristics similar to those of EAC, including Barrett’s adenocarcinoma, might be increasing.

Keywords

Esophageal adenocarcinoma Esophagogastric junction adenocarcinoma Barrett’s adenocarcinoma Barrett’s esophagus Gastric adenocarcinoma 

Notes

Acknowledgements

We thank Angela Morben, DVM, and ELS from Edanz Group (www.edanzediting.com/ac) for editing a draft of this manuscript.

Compliance with ethical standards

Conflict of interest

The authors have no financial conflicts of interest to disclose concerning the study.

Supplementary material

535_2019_1577_MOESM1_ESM.docx (12 kb)
Supplementary material 1 (DOCX 11 kb)

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Copyright information

© Japanese Society of Gastroenterology 2019

Authors and Affiliations

  • Kenshi Matsuno
    • 1
    • 4
  • Ryu Ishihara
    • 1
    Email author
  • Masayasu Ohmori
    • 1
  • Hiroyoshi Iwagami
    • 1
  • Satoki Shichijyo
    • 1
  • Akira Maekawa
    • 1
  • Takashi Kanesaka
    • 1
  • Sachiko Yamamoto
    • 1
  • Yoji Takeuchi
    • 1
  • Koji Higashino
    • 1
  • Noriya Uedo
    • 1
  • Takashi Matsunaga
    • 2
  • Toshitaka Morishima
    • 3
  • Isao Miyashiro
    • 3
  1. 1.Department of Gastrointestinal OncologyOsaka International Cancer InstituteOsakaJapan
  2. 2.Department of Medical InformaticsOsaka International Cancer InstituteOsakaJapan
  3. 3.Cancer Control CenterOsaka International Cancer InstituteOsakaJapan
  4. 4.Department of Gastroenterology and Hepatology, Graduate School of Medical SciencesKumamoto UniversityKumamotoJapan

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