Journal of Gastroenterology

, Volume 54, Issue 1, pp 33–41 | Cite as

Progress in characterizing the linkage between Fusobacterium nucleatum and gastrointestinal cancer

  • Yang Liu
  • Yoshifumi Baba
  • Takatsugu Ishimoto
  • Masaaki Iwatsuki
  • Yukiharu Hiyoshi
  • Yuji Miyamoto
  • Naoya Yoshida
  • Rong Wu
  • Hideo Baba


Microbiome research is a rapidly advancing field in human cancers. Fusobacterium nucleatum is an oral bacterium, indigenous to the human oral cavity, that plays a role in periodontal disease. Recent studies have found that F. nucleatum can promote gastrointestinal tumor progression and affect the prognosis of the disease. In addition, F. nucleatum may contribute to the chemo-resistance of gastrointestinal cancers. This review summarizes recent progress in the pathogenesis of F. nucleatum and its impact on gastrointestinal cancer.


Fusobacterium nucleatum Microbiome Gastrointestinal cancer Colon cancer Esophageal cancer 



This work was supported in part by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science, Grant numbers 17H04273, 17K19702 and 17KK0195 (to Y.B.).

Compliance with ethical standards

Conflict of interest

There is no conflict of interest.


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Copyright information

© Japanese Society of Gastroenterology 2018

Authors and Affiliations

  1. 1.Department of Gastroenterological Surgery, Graduate School of Medical SciencesKumamoto UniversityKumamotoJapan
  2. 2.Second Oncology DepartmentShengjing Hospital of China Medical UniversityShenyangChina
  3. 3.International Research Center for Medical Sciences, Kumamoto UniversityKumamotoJapan

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