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Marked impact of tumor location on the appropriate cutoff values and the prognostic significance of the lymph node ratio in stage III colon cancer: a multi-institutional retrospective analysis

  • Eiji ShintoEmail author
  • Hideyuki Ike
  • Jin-ichi Hida
  • Hirotoshi Kobayashi
  • Yojiro Hashiguchi
  • Yoshiki Kajiwara
  • Kazuo Hase
  • Hideki Ueno
  • Kenichi Sugihara
Original Article—Alimentary Tract
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Abstract

Background

The prognostic significance of lymph node ratio (LNR) is not constant among studies. Exploration of appropriate location-specific cutoffs might be necessary because the number of lymph nodes harvested is generally higher in right than in left colon cancer. We aimed to determine appropriate cutoff values of LNR in right and left colon cancer and to clarify its clinical significance.

Methods

The clinicopathologic data of 5463 patients with stage III colon cancer were collected. The best cutoff for LNR as a prognostic indicator for patients with right and left colon cancer was studied separately. We compared the prognostic impact between LNR and the number of lymph node metastasis using the Akaike information criterion (AIC), and evaluated the prognostic significance of LNR in each stage III subcategory.

Results

The best performance was noted when LNR was categorized by cutoffs of 0.16 and 0.22 for right and left colon cancer, respectively. AIC scores were better with these categorizations than with subgrouping by number of positive nodes. LNR-low right colon cancer patients showed better cancer-specific survival than LNR-high in stage IIIA (95.7% vs. 89.3%), IIIB (86.7% vs. 77.2%), and IIIC (71.2% vs. 58.7%). The same results were obtained in left colon cancer patients with stage IIIB (88.3% vs. 80.7%) and IIIC (79.8% vs. 68.4%).

Conclusions

We demonstrated the difference in the appropriate cutoffs of LNR between right and left colon cancer. Categorization by location-specific cutoff of LNR may be useful for risk stratification of patients with stage III cancer.

Keywords

Lymph node ratio The number of lymph nodes Stage III colon cancer Sidedness 

Notes

Acknowledgements

This work was supported by the Japanese Society for Cancer of the Colon and Rectum. The authors acknowledge Associate Professor Takahiro Nakamura for his contribution to the statistical analysis.

Compliance with ethical standards

Conflict of interest

All authors declare that they have no conflict of interest.

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Copyright information

© Japanese Society of Gastroenterology 2019

Authors and Affiliations

  • Eiji Shinto
    • 1
    Email author return OK on get
  • Hideyuki Ike
    • 2
  • Jin-ichi Hida
    • 3
  • Hirotoshi Kobayashi
    • 4
  • Yojiro Hashiguchi
    • 5
  • Yoshiki Kajiwara
    • 1
  • Kazuo Hase
    • 1
  • Hideki Ueno
    • 1
  • Kenichi Sugihara
    • 6
  1. 1.Department of SurgeryNational Defense Medical CollegeTokorozawaJapan
  2. 2.Department of SurgerySaiseikai Yokohamashi Nanbu HospitalYokohamaJapan
  3. 3.Department of SurgeryKindai University School of MedicineHigashiosakaJapan
  4. 4.Department of SurgeryTokyo Metropolitan Hiroo HospitalTokyoJapan
  5. 5.Department of SurgeryTeikyo University School of MedicineTokyoJapan
  6. 6.Tokyo Medical and Dental UniversityTokyoJapan

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