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Usefulness of transabdominal ultrasonography for assessing ulcerative colitis: a prospective, multicenter study

  • Kenji Kinoshita
  • Takehiko Katsurada
  • Mutsumi Nishida
  • Satomi Omotehara
  • Reizo Onishi
  • Katsuhiro Mabe
  • Aki Onodera
  • Mami Sato
  • Kazunori Eto
  • Mitsutoshi Suya
  • Atsuo Maemoto
  • Toru Hasegawa
  • Junji Yamamoto
  • Daiki Mitsumori
  • Shinji Yoshii
  • Kota Ono
  • Naoya Sakamoto
Original Article—Alimentary Tract
  • 67 Downloads

Abstract

Background

Transabdominal ultrasonography (US) has been reported to be a useful tool for evaluating ulcerative colitis (UC) although with less well-established data than for Crohn’s disease. This prospective multicenter study aimed to establish the usefulness of US compared with colonoscopy (CS) for assessing disease extent and activity of UC.

Methods

Altogether, 173 patients with UC were prospectively enrolled, among whom 156 were eligible for this study. All patients underwent US and CS within 2 days at five facilities. We divided the colon into six segments and examined each segment and the rectum using US and CS. US severity was graded 1–4 regarding bowel wall thickness, stratification, and ulceration. CS severity was also graded 1–4 according to Matts’ endoscopic classification. Concordance between US and CS grades for all colonic segments was analyzed using kappa statistics. US and CS findings were also compared with the clinical disease activity index (CAI) and histological grade using Spearman's correlation coefficient.

Results

There was moderate concordance between US and CS grades in all colonic segments (weighted κ = 0.55, p < 0.001). Concordance was rated moderate for each colonic segment but only slight for the rectum. The US grade was significantly correlated with the CAI score (r = 0.40, p < 0.001) and histological grade (r = 0.35, p < 0.001).

Conclusions

This prospective multicenter study showed moderate concordance between US and CS for assessing the disease activity of UC. Hence, US may be used more generally for evaluating UC in daily clinical practice.

Keywords

Ulcerative colitis Transabdominal ultrasonography Colonoscopy 

Notes

Acknowledgements

The authors would like to thank all the endoscopists and sonographers who participated in this study. This manuscript has been proofread by Edanz Group (https://www.edanzediting.com/ac).

Funding

None.

Compliance with ethical standards

Conflict of interest

The authors declare no conflicts of interest associated with this manuscript.

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Copyright information

© Japanese Society of Gastroenterology 2018

Authors and Affiliations

  • Kenji Kinoshita
    • 1
  • Takehiko Katsurada
    • 1
  • Mutsumi Nishida
    • 2
    • 3
  • Satomi Omotehara
    • 2
    • 3
  • Reizo Onishi
    • 1
  • Katsuhiro Mabe
    • 4
  • Aki Onodera
    • 5
  • Mami Sato
    • 5
  • Kazunori Eto
    • 6
  • Mitsutoshi Suya
    • 7
  • Atsuo Maemoto
    • 8
  • Toru Hasegawa
    • 9
  • Junji Yamamoto
    • 10
  • Daiki Mitsumori
    • 11
  • Shinji Yoshii
    • 12
  • Kota Ono
    • 13
  • Naoya Sakamoto
    • 1
  1. 1.Department of Gastroenterology and HepatologyHokkaido University Graduate School of MedicineSapporoJapan
  2. 2.Division of Laboratory and Transfusion MedicineHokkaido University HospitalSapporoJapan
  3. 3.Diagnostic Center for SonographyHokkaido University HospitalSapporoJapan
  4. 4.Department of GastroenterologyNational Hospital Organization Hakodate HospitalHakodateJapan
  5. 5.Department of Clinical LaboratoryTomakomai City HospitalTomakomaiJapan
  6. 6.Department of GastroenterologyTomakomai City HospitalTomakomaiJapan
  7. 7.Department of Clinical LaboratorySapporo Higashi Tokushukai HospitalSapporoJapan
  8. 8.Inflammatory Bowel Disease CenterSapporo Higashi Tokushukai HospitalSapporoJapan
  9. 9.Department of Clinical LaboratoryOhguro Gastroenterological HospitalSapporoJapan
  10. 10.Ohguro Gastroenterological HospitalSapporoJapan
  11. 11.Department of Clinical LaboratorySapporo Medical Center NTT ECSapporoJapan
  12. 12.Department of GastroenterologySapporo Medical Center NTT ECSapporoJapan
  13. 13.Clinical Research and Medical Innovation CenterHokkaido University HospitalSapporoJapan

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