Journal of Gastroenterology

, Volume 52, Issue 8, pp 992–1000 | Cite as

Nationwide epidemiological survey of early chronic pancreatitis in Japan

  • Atsushi Masamune
  • Kazuhiro Kikuta
  • Tatsuhide Nabeshima
  • Eriko Nakano
  • Morihisa Hirota
  • Atsushi Kanno
  • Kiyoshi Kume
  • Shin Hamada
  • Tetsuhide Ito
  • Motokazu Fujita
  • Atsushi Irisawa
  • Masanori Nakashima
  • Keiji Hanada
  • Takaaki Eguchi
  • Ryusuke Kato
  • Osamu Inatomi
  • Akio Shirane
  • Yoshifumi Takeyama
  • Ichiro Tsuji
  • Tooru Shimosegawa
  • Research Committee of Intractable Pancreatic Diseases in Japan
Original Article—Liver, Pancreas, and Biliary Tract



The world’s first diagnostic criteria for early CP were proposed in 2009 in Japan. This study aimed to clarify the clinico-epidemiological features of early CP in Japan.


Patients with early CP who were diagnosed according to the diagnostic criteria for early CP and had visited the selected hospitals in 2011 were surveyed. The study consisted of two-stage surveys: the number of patients with early CP was estimated by the first questionnaire and their clinical features were assessed by the second questionnaire.


The estimated number of early CP patients was 5410 (95% confidence interval 3675–6945), with an overall prevalence of 4.2 per 100,000 persons. The number of patients who were newly diagnosed with early CP was estimated to be 1330 (95% confidence interval 1058–1602), with an annual incidence of 1.0 per 100,000 persons. Detailed clinical information was obtained in 151 patients in the second survey. The male-to-female sex ratio was 1.32:1. The mean age was 60.4 and the mean age at disease onset was 55.4. Idiopathic (47.7%) and alcoholic (45.0%) were the two most common etiologies. Proportions of female and idiopathic cases were higher in early CP than in definite CP. Hyperechoic foci without shadowing and stranding were the most common findings on endoscopic ultrasonography. The clinical profiles of early CP patients who showed lobularity with honeycombing on endoscopic ultrasonography or previous episodes of acute pancreatitis were similar to those of definite CP patients.


We clarified the current status of early CP in Japan.


Alcohol Diagnosis Endoscopic ultrasonography Epidemiology Functional dyspepsia 



Autoimmune pancreatitis


Acute pancreatitis


Chronic pancreatitis


Diagnostic criteria for early CP


Endoscopic retrograde cholangiopancreatography


Endoscopic ultrasonography


Standard deviation



The authors are grateful to the doctors who kindly replied to the questionnaires. This work was supported in part by the Ministry of Health, Labour, and Welfare of Japan (to YT and TS).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

535_2017_1311_MOESM1_ESM.doc (35 kb)
Supplementary material 1 (DOC 35 kb)


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Copyright information

© Japanese Society of Gastroenterology 2017

Authors and Affiliations

  • Atsushi Masamune
    • 1
  • Kazuhiro Kikuta
    • 1
  • Tatsuhide Nabeshima
    • 1
  • Eriko Nakano
    • 1
  • Morihisa Hirota
    • 1
  • Atsushi Kanno
    • 1
  • Kiyoshi Kume
    • 1
  • Shin Hamada
    • 1
  • Tetsuhide Ito
    • 2
  • Motokazu Fujita
    • 3
  • Atsushi Irisawa
    • 4
  • Masanori Nakashima
    • 5
  • Keiji Hanada
    • 6
  • Takaaki Eguchi
    • 7
  • Ryusuke Kato
    • 8
  • Osamu Inatomi
    • 9
  • Akio Shirane
    • 10
  • Yoshifumi Takeyama
    • 11
  • Ichiro Tsuji
    • 12
  • Tooru Shimosegawa
    • 1
  • Research Committee of Intractable Pancreatic Diseases in Japan
  1. 1.Division of GastroenterologyTohoku University Graduate School of MedicineSendaiJapan
  2. 2.Department of Medicine and Bioregulatory Science, Graduate School of Medical SciencesKyushu UniversityFukuokaJapan
  3. 3.Department of GastroenterologyToyohashi Municipal HospitalToyohashiJapan
  4. 4.Department of Gastroenterology, Aizu Medical CenterFukushima Medical UniversityAizu-WakamatsuJapan
  5. 5.Department of GastroenterologyGifu Municipal HospitalToyohashiJapan
  6. 6.Department of GastroenterologyJA Onomichi General HospitalOnomichiJapan
  7. 7.Department of Gastroenterology and HepatologyOsaka Saiseikai Nakatsu HospitalOsakaJapan
  8. 8.Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical ScienceKyoto Prefectural University of MedicineKyotoJapan
  9. 9.Department of MedicineShiga University of Medical ScienceOtsuJapan
  10. 10.Shirane Gastrointestinal ClinicSendaiJapan
  11. 11.Department of Surgery, Faculty of MedicineKindai UniversityOsakaJapan
  12. 12.Division of Epidemiology, Department of Public Health and Forensic MedicineTohoku University Graduate School of MedicineSendaiJapan

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