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Journal of Gastroenterology

, Volume 51, Issue 11, pp 1050–1062 | Cite as

A population-based study examining the risk of malignancy in patients diagnosed with inflammatory bowel disease

  • J. Claire Wilson
  • Raoul I. Furlano
  • Susan S. Jick
  • Christoph R. MeierEmail author
Original Article—Alimentary Tract

Abstract

Background

Recent studies suggest an increased risk of malignancy in patients with inflammatory bowel disease (IBD), although the findings were inconsistent. We used data from the clinical practice research datalink (CPRD) to further examine this association.

Methods

Patients with a first-time diagnosis of IBD were randomly matched to an equally sized IBD-free comparison group. Multivariable adjusted hazard ratios (AHRs) for cancer risk were estimated using Cox’s proportional hazard regression. A nested case–control analysis comprising IBD patients only was then conducted using conditional logistic regression to estimate the risk of cancer development according to IBD severity, disease duration and IBD therapy.

Results

We identified 1077 cancers among 39,294 IBD or IBD-free patients followed between 1995 and 2012. There was no association between IBD and overall risk of cancer [AHR 1.11, 95 % confidence interval (CI) 0.98–1.25], but a borderline increase in the risk of lymphoproliferative malignancies was observed in patients with IBD (AHR 1.49, 95 % CI 1.00–2.23). Aminosalicylate use was significantly associated with reduced risk of all cancers [adjusted odds ratio (AOR), 0.72, 95 % CI 0.54–0.96], of intestinal cancer (AOR 0.33, 95 % 0.12–0.89) and of prostate cancer (AOR 0.32, 95 % 0.13–0.80).

Conclusions

There was no increased risk of cancer overall in individuals with IBD compared to IBD-free individuals. Consistent with previous findings, a reduction in cancer risk was observed in IBD patients using aminosalicylates, with a substantial reduction in prostate cancer risk. Further large-scale studies examining the relationship between IBD therapy and cancer risk appear to be warranted.

Keywords

Malignancy Inflammatory bowel disease Observational study Cancer risk 

Notes

Acknowledgments

The authors thank BPU data programmer Mr. Pascal Egger for his important contribution to the study.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Financial support

European Crohn’s and Colitis Organisation 2012 Fellowship.

Supplementary material

535_2016_1199_MOESM1_ESM.docx (22 kb)
Supplementary material 1 (DOCX 21 kb)

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Copyright information

© Japanese Society of Gastroenterology 2016

Authors and Affiliations

  • J. Claire Wilson
    • 1
  • Raoul I. Furlano
    • 2
  • Susan S. Jick
    • 3
  • Christoph R. Meier
    • 1
    • 4
    • 5
    Email author
  1. 1.Basel Pharmacoepidemiology Unit (BPU), Division of Clinical Pharmacy and Epidemiology, Department of Pharmaceutical SciencesUniversity of BaselBaselSwitzerland
  2. 2.University Childrens Hospital BaselBaselSwitzerland
  3. 3.Boston Collaborative Drug Surveillance ProgramBoston University School of Public HealthLexingtonUSA
  4. 4.University Hospital BaselBaselSwitzerland
  5. 5.Hospital PharmacyBaselSwitzerland

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