Journal of Gastroenterology

, Volume 49, Issue 2, pp 317–323

Impairment of health-related quality of life in patients with chronic hepatitis C is associated with insulin resistance

  • Takuya Kuwashiro
  • Toshihiko Mizuta
  • Yasunori Kawaguchi
  • Shinji Iwane
  • Hirokazu Takahashi
  • Noriko Oza
  • Satoshi Oeda
  • Hiroshi Isoda
  • Yuichiro Eguchi
  • Iwata Ozaki
  • Keizo Anzai
  • Kazuma Fujimoto
Original Article—Liver, Pancreas, and Biliary Tract

DOI: 10.1007/s00535-013-0781-6

Cite this article as:
Kuwashiro, T., Mizuta, T., Kawaguchi, Y. et al. J Gastroenterol (2014) 49: 317. doi:10.1007/s00535-013-0781-6

Abstract

Background

Although it has been reported that hepatitis C virus (HCV) infection is associated with a significant decline in health-related quality of life (HRQOL), the underlying causes and mechanisms are still unknown. Insulin resistance (IR) is recognized as a distinct aspect of chronic HCV infection. Therefore, we attempted to identify the factors including IR indices that are related to the HRQOL of patients with chronic hepatitis C (CHC).

Methods

One hundred and seventy-five CHC patients (91 female, 84 male, mean age, 56.4 years) not using antidiabetic agents were included and underwent a 75-g oral glucose tolerance test (OGTT) and completed a self-administered HRQOL questionnaire, the Short Form 36 (SF-36), which is a well-validated questionnaire for assessing general QOL. Scale scores were standardized and summarized into physical and mental component summary (PCS and MCS). We investigated which clinical parameters, including homeostasis model assessment of insulin resistance (HOMA-IR), were associated with decline in PCS and MCS scores in CHC patients.

Results

There were no significant differences in clinical parameters between high and low MCS, but there were significant differences in age, sex, hemoglobin, liver fibrosis, OGTT pattern, and HOMA-IR between high and low PCS. Multivariate analysis showed that HOMA-IR >2 was independently associated with lower PCS (OR 2.92, p < 0.01).

Conclusions

Our results suggest that impairment of HRQOL, especially physical domains, in CHC patients is associated with IR.

Keywords

Chronic hepatitis C Health-related quality of life Insulin resistance 

Copyright information

© Springer Japan 2013

Authors and Affiliations

  • Takuya Kuwashiro
    • 1
  • Toshihiko Mizuta
    • 1
  • Yasunori Kawaguchi
    • 1
  • Shinji Iwane
    • 1
  • Hirokazu Takahashi
    • 1
  • Noriko Oza
    • 1
  • Satoshi Oeda
    • 1
  • Hiroshi Isoda
    • 1
  • Yuichiro Eguchi
    • 1
  • Iwata Ozaki
    • 1
  • Keizo Anzai
    • 1
  • Kazuma Fujimoto
    • 1
  1. 1.Department of Internal MedicineSaga Medical SchoolSagaJapan

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